Author | Martinez, Viviana Fajardo | |
Author | Zhang, Dajie | |
Author | Paiola, Sophia | |
Author | Mok, Thalia | |
Author | Cambou, Mary C. | |
Author | Kerin, Tara | |
Author | Rao, Rashmi | |
Author | Brasil, Patricia | |
Author | Ferreira, Fatima | |
Author | Fuller, Trevon | |
Author | Bhattacharya, Debika | |
Author | Foo, Suan-Sin | |
Author | Chen, Weiqiang | |
Author | Jung, Jae | |
Author | Einspieler, Christa | |
Author | Marschik, Peter B. | |
Author | Nielsen-Saines, Karin | |
Access date | 2023-05-15T23:27:35Z | |
Available date | 2023-05-15T23:27:35Z | |
Document date | 2023 | |
Citation | MARTINEZ, Viviana Fajardo et al. Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study. BMJ Open, v. 13, n. 1, p. 1-9, Jan. 2023. | en_US |
ISSN | 2044-6055 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/58409 | |
Description | Ethics approval The study was approved by Institutional review boards at UCLA (IRB protocol 20-000569) and Fundação Oswaldo Cruz (Fiocruz/National Ethics Committee CONEP 30639420.0.0000.5262) with informed consent obtained from parents. | en_US |
Sponsorship | Simons Foundation Autism Research Initiative (SFARI) (award number 866410 to KN-S); the UCLA W.M. Keck Foundation COVID19 Research Award Programme (award number not available to KN-S) the National Institutes of Health (award number T32MH080634 to MCC; award number AI140718 to KN-S). | en_US |
Language | eng | en_US |
Publisher | BMJ Publishing Group Ltd. | en_US |
Rights | open access | en_US |
Title | Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study | en_US |
Type | Article | en_US |
DOI | 10.1136/bmjopen-2022-069194 | |
Abstract | Objective: To evaluate neuromotor repertoires and developmental milestones in infants exposed to antenatal COVID-19. Design: Longitudinal cohort study. Setting: Hospital-based study in Los Angeles, USA and Rio de Janeiro, Brazil between March 2020 and December 2021.
Participants: Infants born to mothers with COVID-19 during pregnancy and prepandemic control infants from the Graz University Database. Interventions: General movement assessment (GMA) videos between 3 and 5 months post-term age were collected and clinical assessments/developmental milestones evaluated at 6-8 months of age. Cases were matched by gestational age, gender and post-term age to prepandemic neurotypical unexposed controls from the database. Main outcome measures: Motor Optimality Scores Revised (MOS-R) at 3-5 months. Presence of developmental delay (DD) at 6-8 months. Results: 239 infants were enrolled; 124 cases (83 in the USA/41 in Brazil) and 115 controls. GMA was assessed in 115 cases and 115 controls; 25% were preterm. Median MOS-R in cases was 23 (IQR 21-24, range 9-28) vs 25 (IQR 24-26, range 20-28) in controls, p<0.001. Sixteen infants (14%) had MOS-R scores <20 vs zero controls, p<0.001. At 6-8 months, 13 of 109 case infants (12%) failed to attain developmental milestones; all 115 control infants had normal development. The timing of maternal infection in pregnancy (first, second or third trimester) or COVID-19 disease severity (NIH categories asymptomatic, mild/moderate or severe/critical) was not associated with suboptimal MOS-R or DD. Maternal fever in pregnancy was associated with DD (OR 3.7; 95% CI 1.12 to 12.60) but not suboptimal MOS-R (OR 0.25; 95% CI 0.04 to 0.96). Conclusions: Compared with prepandemic controls, infants exposed to antenatal COVID-19 more frequently had suboptimal neuromotor development. | en_US |
Affilliation | University of California Los Angeles. Pediatrics, David Geffen School of Medicine. Los Angeles, CA, USA. | en_US |
Affilliation | University Medical Center Göttingen and Leibniz-ScienceCampus Primate Cognition. Child and Adolescent Psychiatry and Psychotherapy. Göttingen, Germany / iDN - interdisciplinary Developmental Neuroscience. Division of Phoniatrics. Medical University of Graz. Graz, Austria. | en_US |
Affilliation | University of California Los Angeles. Pediatrics, David Geffen School of Medicine. Los Angeles, CA, USA. | en_US |
Affilliation | University of California Los Angeles. David Geffen School of Medicine. Obstetrics and Gynecology. Los Angeles, CA, USA. | en_US |
Affilliation | University of California Los Angeles. David Geffen School of Medicine. Internal Medicine. Los Angeles, CA, USA. | en_US |
Affilliation | University of California Los Angeles. Pediatrics, David Geffen School of Medicine. Los Angeles, CA, USA. | en_US |
Affilliation | University of California Los Angeles. David Geffen School of Medicine. Obstetrics and Gynecology. Los Angeles, CA, USA. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Acute Febrile Illnesses. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Universidade do Rio de Janeiro. Escola de Medicina. Pediatrics. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | University of California Los Angeles. David Geffen School of Medicine. Internal Medicine. Los Angeles, CA, USA. | en_US |
Affilliation | Cancer Biology, Lerner Research Institute. Cleveland Clinic. Cleveland, Ohio, USA. | en_US |
Affilliation | Cancer Biology, Lerner Research Institute. Cleveland Clinic. Cleveland, Ohio, USA. | en_US |
Affilliation | Cancer Biology, Lerner Research Institute. Cleveland Clinic. Cleveland, Ohio, USA. | en_US |
Affilliation | iDN - interdisciplinary Developmental Neuroscience. Division of Phoniatrics. Medical University of Graz. Graz, Austria. | en_US |
Affilliation | University Medical Center Göttingen and Leibniz-ScienceCampus Primate Cognition. Child and Adolescent Psychiatry and Psychotherapy. Göttingen, Germany / iDN - interdisciplinary Developmental Neuroscience. Division of Phoniatrics. Medical University of Graz. Graz, Austria / Center of Neurodevelopmental Disorders. Centre for Psychiatry Research; Department of Women's and Children's Health. Karolinska Institutet. Stockholm, Sweden. | en_US |
Affilliation | University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA. | en_US |
Subject | COVID-19 | en_US |
Subject | Maternal medicine | en_US |
Subject | Paediatric infectious disease & immunisation | en_US |
Subject | Paediatric neurology | en_US |
e-ISSN | 2044-6055 | |