| Author | Peixoto, Sérgio William Viana | |
| Author | Amorim, Juleimar Soares Coelho de | |
| Author | Torres, Karen Cecília Lima | |
| Author | Carvalho, Andréa Teixeira | |
| Author | Martins Filho, Olindo Assis | |
| Author | Costa, Maria Fernanda Furtado Lima | |
| Author | Peixoto, Sérgio William Viana | |
| Access date | 2023-05-16T18:02:12Z | |
| Available date | 2023-05-16T18:02:12Z | |
| Document date | 2020 | |
| Citation | AMORIM, Juleimar Soares Coelho de et al. Inflammatory markers associated with fall recurrence and severity: The Bambuí Cohort Study of Aging. Experimental Gerontology, v. 132, 110837, 2020. oi.org/10.1016/j.exger.2020.110837 | en_US |
| ISSN | 1873-6815 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/58445 | |
| Language | eng | en_US |
| Publisher | Elsevier Inc. | en_US |
| Rights | restricted access | |
| Title | Inflammatory markers associated with fall recurrence and severity: The Bambui Cohort Study of Aging | en_US |
| Type | Article | |
| DOI | 10.1016/j.exger.2020.110837 | |
| Abstract | Background: The aim of this study was to analyze the association between inflammatory markers and recurrent and severe falls in 1304 community-dwelling older adults from the Bambuf Cohort Study of Aging. Methods: Information about falls in the previous 12 months was collected, and classified based on recurrence (two or more falls) and severity (requirement of medical attention). The screened biomarkers included interleukins (IL-1 beta, IL-6, IL-10, and IL-12, TNF), chemokines (CXCL8, CXCL9, CXCL10, CCL2, and CCL5), and high-sensitive C-reactive protein (hs-PCR). Potential confounders included sociodemographic, behavioral, and health indicators. Associations were evaluated through logistic regression, using odds ratios (OR) and 95% confidence intervals (95% CI), with Stata 13.1. Results: The prevalence of recurrent and severe falls was 10.7% and 9.0%, respectively. After adjustments, elevated levels of IL-12 (OR: 1.92; 95% CI: 1.09-3.37) and CXCL9 (OR: 1.67; 95% CI: 1.05-2.66) were found to be associated with recurrent falls, while elevated levels of TNF (OR: 1.58; 95% CI: 1.01-2.50), IL-12 (OR: 2.04; 95% CI: 1.13-3.70), CXCL10 (OR: 1.75; 95% CI: 1.04-2.92), and CCL5 (OR: 1.90; 95% CI: 1.18-3.07) were associated with severe falls. Conclusions: The results highlight a wide range of biomarkers not yet explored in the literature and suggest that inflammation may be an important component of recurrent and severe falls. | en_US |
| Affilliation | Postgraduate Program in Public Health. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Laboratory of Diagnostic and Monitoring Biomarkers René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Faculty of Medicine. University José do Rosário Vellano. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Laboratory of Diagnostic and Monitoring Biomarkers René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Laboratory of Diagnostic and Monitoring Biomarkers René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Center of Studies in Public Health and Aging. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Laboratory of Diagnostic and Monitoring Biomarkers René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Federal University of Minas Gerais. Nursing School. Belo Horizonte, MG, Brazil | en_US |
| Subject | Accidental falls | en_US |
| Subject | Inflammation | en_US |
| Subject | Biomarkers | en_US |
| Embargo date | 2099-12-31 | |
