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| Autor | Oliveira, Claudia Di Lorenzo | |
| Autor | Nunes, Maria Carmo P | |
| Autor | Colosimo, Enrico Antonio | |
| Autor | Lima, Emilly Malveira de | |
| Autor | Cardoso, Clareci S | |
| Autor | Ferreira, Ariela Mota | |
| Autor | Oliveira, Lea Campos de | |
| Autor | Moreira, Carlos Henrique Valente | |
| Autor | Bierrenbach, Ana Luiza | |
| Autor | Haikal, Desireé Sant Ana | |
| Autor | Peixoto, Sérgio William Viana | |
| Autor | Costa, Maria Fernanda Furtado de Lima | |
| Autor | Sabino, Ester Cerdeira | |
| Autor | Ribeiro, Antonio Luiz P | |
| Fecha de acceso | 2023-05-16T18:54:38Z | |
| Fecha de disponibilización | 2023-05-16T18:54:38Z | |
| Fecha de publicación | 2020 | |
| Referencia | OLIVEIRA, Claudia Di Lorenzo et al. Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study. J Am Heart Assoc., v. 9, n. 6, e014176, 2020. doi: 10.1161/JAHA.119.014176. | en_US |
| ISSN | 2047-9980 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/58448 | |
| Idioma | eng | en_US |
| Editor | Wiley-Blackwell | en_US |
| Derechos de autor | open access | en_US |
| Título | Risk Score for Predicting 2-Year Mortality in Patients With Chagas Cardiomyopathy From Endemic Areas: SaMi-Trop Cohort Study | en_US |
| Tipo del documento | Article | en_US |
| DOI | 10.1161/JAHA.119.014176 | |
| Resumen en Inglés | Background Risk stratification of Chagas disease patients in the limited-resource setting would be helpful in crafting management strategies. We developed a score to predict 2-year mortality in patients with Chagas cardiomyopathy from remote endemic areas. Methods and Results This study enrolled 1551 patients with Chagas cardiomyopathy from Minas Gerais State, Brazil, from the SaMi-Trop cohort (The SÃO Paulo-Minas Gerais Tropical Medicine Research Center). Clinical evaluation, ECG, and NT-proBNP (N-terminal pro-B-type natriuretic peptide) were performed. A Cox proportional hazards model was used to develop a prediction model based on the key predictors. The end point was all-cause mortality. The patients were classified into 3 risk categories at baseline (low, <2%; intermediate, >= 2% to 10%; high, >= 10%). External validation was performed by applying the score to an independent population with Chagas disease. After 2 years of follow-up, 110 patients died, with an overall mortality rate of 3.505 deaths per 100 person-years. Based on the nomogram, the independent predictors of mortality were assigned points: age (10 points per decade), New York Heart Association functional class higher than I (15 points), heart rate >= 80 beats/min (20 points), QRS duration >= 150 ms (15 points), and abnormal NT-proBNP adjusted by age (55 points). The observed mortality rates in the low-, intermediate-, and high-risk groups were 0%, 3.6%, and 32.7%, respectively, in the derivation cohort and 3.2%, 8.7%, and 19.1%, respectively, in the validation cohort. The discrimination of the score was good in the development cohort (C statistic: 0.82), and validation cohort (C statistic: 0.71). Conclusions In a large population of patients with Chagas cardiomyopathy, a combination of risk factors accurately predicted early mortality. This helpful simple score could be used in remote areas with limited technological resources. | en_US |
| Afiliación | Federal University of São João del-Rei. Divinópolis, MG, Brazil. | en_US |
| Afiliación | Universidade Federal de Minas Gerais. Faculdade de Medicina. Hospital das Clínicas. Belo Horizonte, MG, Brazil. | en_US |
| Afiliación | Universidade Federal de Minas Gerais. Instituto de Ciência Exatas. Department of Statistics. Belo Horizonte, MG, Brazil. | en_US |
| Afiliación | Universidade Federal de Minas Gerais. Instituto de Ciência Exatas. Department of Statistics. Belo Horizonte, MG, Brazil. | en_US |
| Afiliación | Federal University of São João del-Rei. Divinópolis, MG, Brazil. | en_US |
| Afiliación | Health Science Program Universidade Estadual de Montes Claros Montes Claros Brazil. | en_US |
| Afiliación | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas. Laboratório de Investigação Médica. São Paulo, SP, Brazil. | en_US |
| Afiliación | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas. Laboratório de Investigação Médica. São Paulo, SP, Brazil. | en_US |
| Afiliación | Hospital Sírio-Libanês. Research and Education Institute. São Paulo, SP, Brazil. | en_US |
| Afiliación | Health Science Program Universidade Estadual de Montes Claros Montes Claros Brazil. | en_US |
| Afiliación | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Afiliación | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Afiliación | Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical e Departamento de Moléstias Infecciosas e Parasitarias. São Paulo, SP, Brazil. | en_US |
| Afiliación | Universidade Federal de Minas Gerais. Faculdade de Medicina. Hospital das Clínicas. Belo Horizonte, MG, Brazil. | en_US |
| Palavras clave en Inglês | Chagas cardiomyopathy | en_US |
| Palavras clave en Inglês | Chagas disease | en_US |
| Palavras clave en Inglês | mortality | en_US |
| Palavras clave en Inglês | isk prediction | en_US |
| Palavras clave en Inglês | risk score | en_US |
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