| Author | Pereira, Wille Dingsor Souza | |
| Author | Lelis, Deborah de Farias | |
| Author | Cunha, Roberto de Sá | |
| Author | Griep, Rosane Harter | |
| Author | Barreto, Sandhi Maria | |
| Author | Molina, Maria del Carmen Bisi | |
| Author | Schmidt, Maria Inês | |
| Author | Duncan, Bruce Bartholow | |
| Author | Bensenor, Isabela Judith Martins | |
| Author | Lotufo, Paulo Andrade | |
| Author | Mill, José Geraldo | |
| Author | Baldo, Marcelo Perim | |
| Access date | 2023-05-17T20:13:50Z | |
| Available date | 2023-05-17T20:13:50Z | |
| Document date | 2024 | |
| Citation | PEREIRA, Wille Dingsor Souza et al. Fasting glucose, glycated hemoglobin, and 2h post-load blood glucose are independently associated with arterial stiffness in diabetes: the ELSA-Brasil Study. Angiology: The Journal of Vascular Diseases, v. 75, n. 7, p. 635-644, Aug. 2024. | |
| ISSN | 0003-3197 | |
| URI | https://www.arca.fiocruz.br/handle/icict/58465 | |
| Description | Produção científica do Laboratório de Educação em Ambiente e Saúde. | pt_BR |
| Sponsorship | Brazilian Ministry of Health (Department of Science and Technology) and Ministry of Science, Technology, and Innovation (FINEP, Financiadora de Estudos e Projetos), Grants No. 01 06 0010.00, 01 06 0212.00, 01 06 0300.00, 01 06 0278.00, 01 06 0115.00 and 01 06 0071.00. | en_US |
| Sponsorship | CNPq (the National Council for Scientific and Technological Development) | en_US |
| Language | eng | en_US |
| Publisher | SAGE Publications | |
| Rights | restricted access | |
| Title | Fasting glucose, glycated hemoglobin, and 2h post-load blood glucose are independently associated with arterial stiffness in diabetes: the ELSA-Brasil Study | en_US |
| Type | Article | |
| DOI | 10.1177/00033197231166180 | |
| Abstract | The association of diabetes with increased large artery stiffness is not definitively established. We aimed to describe the carotid-femoral pulse wave velocity (cf-PWV) in participants with and without diabetes and whether the cf-PWV could vary among the different laboratory-based criteria used. A cross-sectional analysis using baseline data from 13,912 adults was used. cf-PWV as well as anthropometric, biochemical, and clinical data were measured. Diabetes was defined by previous medical diagnosis, medication use, fasting glucose, an oral glucose tolerance test (GTT), or glycated hemoglobin (HbA1c). The prevalence of diabetes was 18.7%, higher in men than in women. After adjustment, participants with diabetes showed higher cf-PWV (men: 9.7 ± 1.7 vs 9.4 ± 1.7 m/s, P < .05; women: 9.4 ± 1.6 vs 9.1 ± 1.7 m/s, P < .05). We observed a progressive increase in cf-PWV as >1 laboratory-based criterion for diabetes diagnosis was reached. Also, participants with diabetes with alterations in any laboratory-based criteria had higher cf-PWV than participants without diabetes, regardless of sex. In summary, diabetes is associated with higher cf-PWV as is each laboratory-based parameter used for its diagnosis. These results support the strong consequences of glucose dysregulation on the vascular system and provide evidence to screen all parameters involved in glycemic metabolism to improve vascular health. | en_US |
| Affilliation | Universidade Estadual de Montes Claros. Centro de Ciências Biológicas e da Saúde. Departamento de Fisiopatologia. Montes Claros, MG, Brasil. | |
| Affilliation | Universidade Estadual de Montes Claros. Centro de Ciências Biológicas e da Saúde. Departamento de Fisiopatologia. Montes Claros, MG, Brasil. | |
| Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Hospital das Clínicas. Empresa Brasileira de Serviços Hospitalares - Hospitais Universitários Federais. Belo Horizonte, MG, Brasil. | |
| Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Programa de Pós-Graduação em Saúde Coletiva. Vitória, ES, Brasil. | |
| Affilliation | Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Porto Alegre, RS, Brasil. | |
| Affilliation | Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Porto Alegre, RS, Brasil. | |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | |
| Affilliation | Universidade Federal do Espírito Santo. Centro de Ciências da Saúde. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | |
| Affilliation | Universidade Estadual de Montes Claros. Centro de Ciências Biológicas e da Saúde. Departamento de Fisiopatologia. Montes Claros, MG, Brasil. | |
| Subject | Arterial stiffness | en_US |
| Subject | Diabetes | en_US |
| Subject | Fasting glucose | en_US |
| Subject | HbA1c | en_US |
| Subject | 2h post-load blood glucose | en_US |
| e-ISSN | 1940-1574 | |
