Author | Abreu, Rayane da Silva | |
Author | Antunes, Deborah | |
Author | Moreira, Aline dos Santos | |
Author | Passetti, Fabio | |
Author | Mendonça, Julia Badaró | |
Author | Araújo, Natássia Silva de | |
Author | Sassaro, Tayanne Felippe | |
Author | Alberto, Anael Viana Pinto | |
Author | Carrossini, Nina | |
Author | Fernandes, Priscila Valverde | |
Author | Costa, Mayla Abrahim | |
Author | Guimarães, Ana Carolina Ramos | |
Author | Degrave, Wim Maurits Sylvain | |
Author | Waghabi, Mariana Caldas | |
Access date | 2023-05-22T12:42:33Z | |
Available date | 2023-05-22T12:42:33Z | |
Document date | 2023 | |
Citation | ABREU, Rayane da Silva et al. Next generation of ovarian cancer detection using aptamers. Int. J. Mol. Sci, v. 24, n. 6315, p. 1-28, 2023. | en_US |
ISSN | 1422-0067 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/58543 | |
Language | por | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Title | Next generation of ovarian cancer detection using aptamers | en_US |
Type | Article | en_US |
DOI | https:// doi.org/10.3390/ijms24076315 | |
Abstract | Ovarian cancer is among the seven most common types of cancer in women, being the most fatal gynecological tumor, due to the difficulty of detection in early stages. Aptamers are important tools to improve tumor diagnosis through the recognition of specific molecules produced by tumors. Here, aptamers and their potential targets in ovarian cancer cells were analyzed by in silico approaches. Specific aptamers were selected by the Cell-SELEX method using Caov-3 and OvCar-3 cells. The five most frequent aptamers obtained from the last round of selection were computationally modeled. The potential targets for those aptamers in cells were proposed by analyzing proteomic data available for the Caov-3 and OvCar-3 cell lines. Overexpressed proteins for each cell were characterized as to their three-dimensional model, cell location, and electrostatic potential. As a result, four specific aptamers for ovarian tumors were selected: AptaC2, AptaC4, AptaO1, and AptaO2. Potential targets were identified for each aptamer through Molecular Docking, and the best complexes were AptaC2-FXYD3, AptaC4-ALPP, AptaO1-TSPAN15, and AptaO2-TSPAN15. In addition, AptaC2 and AptaO1 could detect different stages and subtypes of ovarian cancer tissue samples. The application of this technology makes it possible to propose new molecular biomarkers for the differential diagnosis of epithelial ovarian cancer. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Instituto Nacional de Tecnologia. Laboratório de Tecnologia de Pós. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Instituto Nacional do Câncer. Divisão de Patologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Instituto Nacional do Câncer. Divisão de Patologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia Imunológica. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | Carcinoma, Ovarian Epithelial | en_US |
Subject | Aptamers | en_US |
Subject | Computer Simulation | en_US |
Subject in Spanish | Carcinoma Epitelial de Ovario | en_US |
Subject in Spanish | Aptámeros | en_US |
Subject in Spanish | Simulación por Computador | en_US |
Subject in French | Carcinome épithélial de l'ovaire | en_US |
Subject in French | Aptamères | en_US |
Subject in French | Simulation numérique | en_US |
DeCS | Carcinoma Epitelial do Ovário | en_US |
DeCS | Aptâmeros | en_US |
DeCS | Modelagem Computacional | en_US |