| Author | Batista, Marina Andrade | |
| Author | Calvo-Fortes, Fernanda | |
| Author | Silveira-Nunes, Gabriela | |
| Author | Camatta, Giovanna Caliman | |
| Author | Speziali, Elaine | |
| Author | Turroni, Silvia | |
| Author | Carvalho, Andrea Teixeira de | |
| Author | Martins Filho, Olindo Assis | |
| Author | Neretti, Nicola | |
| Author | Maioli, Tatiani Uceli | |
| Author | Santos, Rodrigo Ribeiro | |
| Author | Brigidi, Patrizia | |
| Author | Franceschi, Claudio | |
| Author | Faria, Ana Maria Caetano | |
| Access date | 2023-05-23T19:18:49Z | |
| Available date | 2023-05-23T19:18:49Z | |
| Document date | 2020 | |
| Citation | BATISTA, Marina Andrade et al. Inflammaging in Endemic Areas for Infectious Diseases. Front Immunol., v. 11, 579972, 2020. doi: 10.3389/fimmu.2020.579972. | en_US |
| ISSN | 1664-3224 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/58597 | |
| Language | eng | en_US |
| Publisher | Frontiers Research Foundation | en_US |
| Rights | open access | en_US |
| Title | Inflammaging in Endemic Areas for Infectious Diseases | en_US |
| Type | Article | en_US |
| DOI | 10.3389/fimmu.2020.579972 | |
| Abstract | Immunosenescence is marked by a systemic process named inflammaging along with a series of defects in the immunological activity that results in poor responses to infectious agents and to vaccination. Inflammaging, a state of low-grade chronic inflammation, usually leads to chronic inflammatory diseases and frailty in the elderly. However, some elderly escape from frailty and reach advanced age free of the consequences of inflammaging. This process has been called immunological remodeling, and it is the hallmark of healthy aging as described in the studies of centenarians in Italy. The biological markers of healthy aging are still a matter of debate, and the studies on the topic have focused on inflammatory versus remodeling processes and molecules. The sub-clinical inflammatory status associated with aging might be a deleterious event for populations living in countries where chronic infectious diseases are not prevalent. Nevertheless, in other parts of the world where they are, two possibilities may occur. Inflammatory responses may have a protective effect against these infectious agents. At the same time, the long-term consequences of protective immune responses during chronic infections may result in accelerated immunosenescence in these individuals. Therefore, the biological markers of healthy aging can vary according to environmental, cultural, and geographical settings that reflect worldwide, and in a non-biased, non-westernized perspective, the changes that we experience regarding our contacts with microorganisms and the outcomes of such contacts. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós Graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós Graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Juiz de Fora. Departamento de Medicina. Governador Valadares, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós Graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Unit of Microbial Ecology of Health. Department of Pharmacy and Biotechnology. University of Bologna. Bologna, Italy. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Departament of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, United States. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós Graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Unit of Microbial Ecology of Health. Department of Pharmacy and Biotechnology. University of Bologna. Bologna, Italy. | en_US |
| Affilliation | Center for Biophysics, Bioinformatics, Biocomplexity. University of Bologna. Bologna, Italy/Laboratory of Systems Biology of Healthy Aging, Department of Applied Mathematics, Lobachevsky University, Nizhny Novgorod, Russia. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Escola de Enfermagem. Programa de Pós Graduação em Nutrição e Saúde. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Subject | aging | en_US |
| Subject | chronic infection | en_US |
| Subject | dietary components | en_US |
| Subject | genetics | en_US |
| Subject | inflammaging | en_US |
| Subject | inflammation | en_US |
| Subject | microbiota | en_US |
