| Autor | Lima, Flávia Oliveira de | |
| Autor | Nonato, Fabiana Regina | |
| Autor | Couto, Ricardo David | |
| Autor | Barbosa Filho, José Maria | |
| Autor | Nunes, Xirley Pereira | |
| Autor | Santos, Ricardo Ribeiro dos | |
| Autor | Soares, Milena Botelho Pereira | |
| Autor | Villarreal, Cristiane Flora | |
| Data de acesso | 2012-11-23T18:03:25Z | |
| Data de disponibilização | 2012-11-23T18:03:25Z | |
| Data do publicação | 2011 | |
| Citação | LIMA, F.O. de et al. Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin. Journal of Natural Products, v. 74, n. 4, p. 596-602, apr. 2011. | pt_BR |
| ISSN | 1520-6025 | |
| URI | https://www.arca.fiocruz.br/handle/icict/5864 | |
| Idioma | eng | pt_BR |
| Direito Autoral | open access | |
| Título | Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin. | pt_BR |
| Tipo do documento | Article | pt_BR |
| DOI | 10.1021/np100621c | |
| Resumo em Inglês | 7-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models of pain. However, the biochemical events involved in antinociception mediated by 1 are currently not well understood. In the present study, the mechanisms by which 1 exerts its pharmacological actions were investigated. Acute pretreatment of mice with 1 produced a long-lasting antinociceptive effect against complete Freund's adjuvant (CFA)-induced hyperalgesia. The subchronic administration of 1 inhibited CFA-induced hyperalgesia and paw edema, while it did not cause any apparent toxicity. Another set of experiments showed that 1 inhibited carrageenan-induced mechanical hyperalgesia, but not mechanical hyperalgesia induced by prostaglandin E(2) (PGE(2)), suggesting that it acts upstream of PGE(2.) Treatment with 1 was able to prevent the plantar tissue neutrophil influx induced by local inflammatory stimuli. In addition, 1 exhibited inhibitory effects on the release of hyperalgesic cytokines (TNF-α and IL-1ß) and the production of PGE(2), a directly acting hyperalgesic mediator. The present results suggest that the antinociceptive effect of 1 is correlated with the inhibition of neutrophil migration, cytokine release, and PGE(2) production and are supportive of the further investigation of the therapeutic potential of 1 to control inflammatory pain. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Afiliação | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Afiliação | Universidade Federal da Paraíba. João Pessoa, PB, Brasil | pt_BR |
| Afiliação | Universidade Federal da Paraíba. João Pessoa, PB, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| DeCS | Analgésicos/farmacologia | pt_BR |
| DeCS | Dor/quimioterapia | pt_BR |
| DeCS | Umbeliferonas/farmacologia | pt_BR |
| DeCS | Analgésicos/química | pt_BR |
| DeCS | Analgésicos/metabolismo | pt_BR |
| DeCS | Analgésicos/uso terapêutico | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Brasil | pt_BR |
| DeCS | Dinoprostona/farmacologia | pt_BR |
| DeCS | Edema/induzido quimicamente | pt_BR |
| DeCS | Edema/quimioterapia | pt_BR |
| DeCS | Adjuvante de Freund/farmacologia | pt_BR |
| DeCS | Camundongos | pt_BR |
| DeCS | Modelos Animais | pt_BR |
| DeCS | Estrutura Molecular | pt_BR |
| DeCS | Neutrófilos/efeitos de drogas | pt_BR |
| DeCS | Neutrófilos/fisiologia | pt_BR |
| DeCS | Dor/induzido quimicamente | pt_BR |
| DeCS | Medição da Dor | pt_BR |
| DeCS | Fator de Necrose Tumoral alfa/farmacologia | pt_BR |
| DeCS | Umbeliferonas/química | pt_BR |
| DeCS | Umbeliferonas/uso terapêutico | pt_BR |
