| Author | Kahn, Rebecca | |
| Author | Janusz, Cara B. | |
| Author | Castro, Marcia C. | |
| Author | Matos, Aline da Rocha | |
| Author | Domingues, Carla | |
| Author | Ponmattam, Jamie | |
| Author | Rey-Benito, Gloria | |
| Author | Toscano, Cristiana M. | |
| Author | Oliveira, Lucia Helena de | |
| Author | Regional COVID-19 VE in Adults Study Working Group | |
| Access date | 2023-05-26T14:09:08Z | |
| Available date | 2023-05-26T14:09:08Z | |
| Document date | 2023 | |
| Citation | KHAN, Rebecca et al. The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study. The Lancet Regional Health - Americas. v.20: 100474, p. 1 - 12, 2023. | en_US |
| ISSN | 2667-193X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/58743 | |
| Description | Funding This study was funded by the Pan-American Health Organization (PAHO, World Health Organization
(WHO)). PAHO convened and led the study implementation. | en_US |
| Language | eng | en_US |
| Publisher | Elsevier Ltd. | en_US |
| Rights | open access | |
| Subject in Portuguese | COVID-19 | en_US |
| Subject in Portuguese | Eficácia da vacina | en_US |
| Subject in Portuguese | Controle de caso | en_US |
| Subject in Portuguese | Teste negativo | en_US |
| Subject in Portuguese | Brasil | en_US |
| Subject in Portuguese | Chile | en_US |
| Subject in Portuguese | Argentina | en_US |
| Subject in Portuguese | Colômbia | en_US |
| Title | The effectiveness of COVID-19 vaccines in Latin America, 2021: a multicenter regional case–control study | en_US |
| Type | Article | |
| DOI | 10. 1016/j.lana.2023. 100474 | |
| Abstract | Summary
Background As of September 2022, nearly 1.3 billion doses of COVID-19 vaccine products have been administered in
Latin America and the Caribbean, where 27% of global COVID-19 deaths have occurred. This study aimed to estimate
the effectiveness of COVID-19 vaccines against lab-confirmed COVID-19 related hospitalizations and deaths among
adults in Argentina, Brazil, Chile, and Colombia.
Methods Using a test-negative case control design, we evaluated the effectiveness of a primary vaccination series
considering six COVID-19 vaccine products (Sputnik V, mRNA-1273, CoronaVac, ChAdOx1, BNT162b2,
Ad26.COV2.S) against lab-confirmed COVID-19 hospitalizations and deaths among 83,708 hospitalized adults
from February–December, 2021. Data from hospitalization records, COVID surveillance, and vaccination registries
were used. Vaccine effectiveness was estimated using logistic regression ((1-OR) x 100).
Findings The average age of participants was 56.7 (SD = 17.5), and 45,894 (54.8%) were male. Adjusted VE (aVE)
estimates for full vaccination against hospitalization were 82% for mRNA-1273 (95% confidence interval (CI) = −30 to
98%), 76% (71%–81%) for BNT162b2, 65% (61–68%) for ChAdOx1, 57% (10–79%) for Sputnik V, 53% (50–56%) for
CoronaVac, and 46% (23–62%) for Ad26.COV2.S. Estimates, particularly for CoronaVac, varied by variant.
Decreasing aVE was estimated as age increased, particularly for CoronaVac and ChAdOx1. aVE estimates against
death were generally higher, with 100% (CI not estimated) for mRNA-1273, 82% (69–90%) for BNT162b2, 73%
(69–77%) for ChAdOx1, 65% (60–67%) for CoronaVac, 38% (−75 to 78%) for Sputnik V, 6% (−58 to 44%) for
Ad26.COV2.S. | en_US |
| Affilliation | Harvard TH Chan School of Public Health, 677 Huntington Ave Suite 506, Boston, MA, 02115, USA. | en_US |
| Affilliation | University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. | en_US |
| Affilliation | Harvard TH Chan School of Public Health. Boston, MA, 02115, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | SMDB conjunto 12b lote 3 Casa B. Brasília DF, Brasil. | en_US |
| Affilliation | Harvard TH Chan School of Public Health. Boston, MA, 02115, USA. | en_US |
| Affilliation | Immunization Unit, Pan American Health Organization, Washington, USA. | en_US |
| Affilliation | Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil. | en_US |
| Affilliation | Immunization Unit, Pan American Health Organization, Washington, USA. | en_US |
| Subject | COVID-19 | en_US |
| Subject | Vaccine effectiveness | en_US |
| Subject | Case–control | en_US |
| Subject | Test-negative | en_US |
| Subject | Brazil | en_US |
| Subject | Chile | en_US |
| Subject | Argentina | en_US |
| Subject | Colombia | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
