Author | Oliveira, Lílian Maria Garcia Bahia | |
Author | Silva, Juliana Azevedo da | |
Author | Peixoto-Rangel, Alba Lucinia | |
Author | Boechat, Marcela Santana Bastos | |
Author | Abreu, Annelise Maria de Oliveira Wilken de | |
Author | Massara, Cristiano Lara | |
Author | Peixe, Ricardo Guerra | |
Access date | 2023-05-29T16:11:11Z | |
Available date | 2023-05-29T16:11:11Z | |
Document date | 2009 | |
Citation | BAHIA-OLIVEIRA, Lílian Maria Garcia et al. Host immune response to Toxoplasma gondii and Ascaris lumbricoides in a highly endemic area: evidence of parasite co-immunomodulation properties influencing the outcome of both infections. Mem. Inst. Oswaldo Cruz, v. 104, n. 2, 2009. doi.org/10.1590/S0074-02762009000200021 | en_US |
ISSN | 0074-0276 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/58798 | |
Language | eng | en_US |
Publisher | Ministério da Saúde | en_US |
Rights | restricted access | en_US |
Title | Host immune response to Toxoplasma gondii and Ascaris lumbricoides in a highly endemic area: evidence of parasite co-immunomodulation properties influencing the outcome of both infections | en_US |
Type | Article | en_US |
DOI | https://doi.org/10.1590/S0074-02762009000200021 | |
Abstract | Toxoplasmosis and ascaridiasis evoke polar Th-1 and Th-2 host immune responses, respectively. A study to investigate the specific cytokine profile production by in vitro cultures of peripheral blood mononuclear cells from individuals living under precarious sanitary conditions in a highly endemic area for the parasites Toxoplasma gondii and Ascaris lumbricoides was conducted. High levels of both IFN-gamma (Th-1) and IL-13 (Th-2) were observed in groups of co-infected individuals presenting toxoplasmic ocular lesions. Significantly lower IL-10 and TGF-beta levels were produced by co-infected individuals in comparison with groups of individuals not infected with A. lumbricoides and either positive or negative for T. gondii living under good sanitary conditions (control groups). The possible influence of co-parasitism on the clinical presentation of ocular toxoplasmosis is discussed | en_US |
Affilliation | Universidade Estadual do Norte Fluminense. Centro de Biociências e Biotecnologia. Laboratório de Biologia do Reconhecer. Campos dos Goytacazes, RJ, Brazil | en_US |
Affilliation | Universidade Estadual do Norte Fluminense. Centro de Biociências e Biotecnologia. Laboratório de Biologia do Reconhecer. Campos dos Goytacazes, RJ, Brazil | en_US |
Affilliation | Universidade Estadual do Norte Fluminense. Centro de Biociências e Biotecnologia. Laboratório de Biologia do Reconhecer. Campos dos Goytacazes, RJ, Brazil | en_US |
Affilliation | Universidade Estadual do Norte Fluminense. Centro de Biociências e Biotecnologia. Laboratório de Biologia do Reconhecer. Campos dos Goytacazes, RJ, Brazil | en_US |
Affilliation | Universidade Estadual do Norte Fluminense. Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brazil | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisas René Rachou. Laboratório de Helmintologia e Malacologia Médica. Belo Horizonte, MG, Brasil | en_US |
Affilliation | Universidade Estadual do Norte Fluminense. Centro de Biociências e Biotecnologia. Laboratório de Biologia do Reconhecer. Campos dos Goytacazes, RJ, Brazil /Universidade Estadual do Norte Fluminense. Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brazil | en_US |
Subject | Toxoplasma gondii | en_US |
Subject | Ascaris lumbricoides | en_US |
Subject | uveitis | en_US |
Subject | retinochoroiditis | en_US |
Subject | environmental contamination | en_US |
Subject | cytokines | en_US |