| Author | Silva, Tatiane Barreto da | |
| Author | Dias, Evellyn Araújo | |
| Author | Cardoso, Liana Monteiro da Fonseca | |
| Author | Gama, Jaciara Fernanda Gomes | |
| Author | Alves, Luiz Anastácio | |
| Author | Henriques-Pons, Andrea | |
| Access date | 2023-06-03T11:09:55Z | |
| Available date | 2023-06-03T11:09:55Z | |
| Document date | 2023 | |
| Citation | SILVA, Tatiane Barreto da et al. Magnetic Nanostructures and Stem Cells for Regenerative Medicine, Application in Liver Diseases. International Journal of Molecular Sciences. v. 24, 9293, p. 1 - 20, May 2023. | en_US |
| ISSN | 1422-0067 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/58914 | |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | |
| Subject in Portuguese | Doenças hepáticas | en_US |
| Subject in Portuguese | Nanopartículas magnéticas | en_US |
| Subject in Portuguese | Medicina regenerativa | en_US |
| Subject in Portuguese | Biomateriais | en_US |
| Title | Magnetic Nanostructures and Stem Cells for Regenerative Medicine, Application in Liver Diseases | en_US |
| Type | Article | |
| DOI | 10.3390/ijms24119293 | |
| Abstract | The term “liver disease” refers to any hepatic condition that leads to tissue damage or
altered hepatic function and can be induced by virus infections, autoimmunity, inherited genetic
mutations, high consumption of alcohol or drugs, fat accumulation, and cancer. Some types of
liver diseases are becoming more frequent worldwide. This can be related to increasing rates of
obesity in developed countries, diet changes, higher alcohol intake, and even the coronavirus disease
2019 (COVID-19) pandemic was associated with increased liver disease-related deaths. Although
the liver can regenerate, in cases of chronic damage or extensive fibrosis, the recovery of tissue
mass is impossible, and a liver transplant is indicated. Because of reduced organ availability, it
is necessary to search for alternative bioengineered solutions aiming for a cure or increased life
expectancy while a transplant is not possible. Therefore, several groups were studying the possibility
of stem cells transplantation as a therapeutic alternative since it is a promising strategy in regenerative
medicine for treating various diseases. At the same time, nanotechnological advances can contribute
to specifically targeting transplanted cells to injured sites using magnetic nanoparticles. In this review,
we summarize multiple magnetic nanostructure-based strategies that are promising for treating
liver diseases. | en_US |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Inovações em Terapias, Educação e Bioprodutos. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Liver diseases | en_US |
| Subject | Magnetic nanoparticles | en_US |
| Subject | Regenerative medicine | en_US |
| Subject | Biomaterials | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
