| Author | Couto-Fernandez, Jose Carlos | |
| Author | Jesus, Carlos Silva de | |
| Access date | 2023-06-03T13:14:48Z | |
| Available date | 2023-06-03T13:14:48Z | |
| Document date | 2022 | |
| Citation | Couto-Fernandez, José Carlos; JESUS, Carlos Silva de. Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil. Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil. J. Biomed Res. Environ. Sci. Sep 15; 3(9): p. 1054-1056, 2022. | en_US |
| ISSN | 2766-2276 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/58915 | |
| Language | eng | en_US |
| Publisher | Medicine Group | en_US |
| Rights | open access | |
| Subject in Portuguese | Baixa Prevalência de HIV-1 Transmitido | en_US |
| Subject in Portuguese | Resistência aos antirretrovirais | en_US |
| Subject in Portuguese | Gestantes | en_US |
| Title | Low Prevalence of Transmitted HIV-1 Antiretroviral Resistance in Pregnant Women from Rio de Janeiro, Brazil | en_US |
| Type | Article | |
| DOI | 10.37871/jbres1554 | |
| Abstract | Background: HIV screening during antenatal care is being expanded in Brazil for early diagnosis
of HIV-1 infection during pregnancy and prevention of vertical transmission. HIV genotyping in
pregnant women is crucial to reduce the risk of vertical transmission in those carrying resistant
strains and may also be used for Transmitted Drug Resistance (TDR) surveillance purpose. We
evaluated prevalence and patterns of HIV-1 TDR and HIV-1 subtype distribution, in recently diagnosed
ARV naïve pregnant women from Rio de Janeiro, Brazil.
Methods: 299 blood samples of recently diagnosed HIV-1-infected pregnant women from
four reference antenatal care public health units in Rio de Janeiro, were consecutively collected
and analyzed from 2005 to 2015. ViroseqTM (Abbott) and TrugeneTM HIV-1 Genotyping Systems
(Siemens) were used for genotyping and the Standford Algorithm for Interpretation of HIV-1
Resistance for TDR and subtype identifi cation.
Results: The most prevalent HIV-1 subtype was the subtype B (79.3%), followed by subtype F
(11.9%), BF recombinant forms (4%), subtype C (2%) and the recombinant forms: CRF02_AG, CRF31_
BC, K/F and DF identifi ed in one subject each. Overall, the associated resistance mutations were
12.6%, 4.3% associated to the Nucleoside Reverse Transcriptase Inhibitors (NRTIs) of the samples,
4.9% to Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) and 3.4% to Protease Inhibitors
(PIs). Mutations associated with NRTI resistance were TAMs, F77L, M184V; associated with NNRTI
resistance were K103N, Y188H and L100I and mutations associated to PIs were D30N, M46I, and
V82L.
Conclusion: HIV-1 subtype B was the most prevalent subtype observed in our study. For the fi rst
time infections with the circulating recombinant forms CRF02_AG and CRF31_BC were described in
a pregnant woman, suggesting the spread of African derived virus in Brazil and the introduction in
Rio de Janeiro of the CRF31_BC coming from South Brazil. Our results strongly suggest the need of
establishing a regular surveillance system for transmitted HIV-1 drug resistance in pregnant women
in Brazil and its integration in antenatal care management policies for HIV-1 infected women should
be considered. | en_US |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de AIDS e Imunologia Molecular, Centro de Referência da OMS para Vigilância da Resistência do HIV-1 (HIVResNet). Rio de Janeiro-RJ, Brasil. | en_US |
| Affilliation | Sem afiliação | en_US |
| Subject | Low Prevalence of Transmitted HIV-1 | en_US |
| Subject | Antiretroviral Resistance in Pregnant Women | en_US |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
