Author | Costa, Rafaela G. A. | |
Author | Silva, Suellen L. R. | |
Author | Dias, Ingrid R. S. B. | |
Author | Oliveira, Maiara de S. | |
Author | Rodrigues, Ana Carolina B. da C. | |
Author | Dias, Rosane B. | |
Author | Bezerra, Daniel P. | |
Access date | 2023-06-05T13:48:51Z | |
Available date | 2023-06-05T13:48:51Z | |
Document date | 2023 | |
Citation | COSTA, Rafaela G.A. et al. Emerging drugs targeting cellular redox homeostasis to eliminate acute myeloid leukemia stem cells. Redox Biology, v. 62, p. 1-13, 102692 | en_US |
ISSN | 2213-2317 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/58925 | |
Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). | en_US |
Language | eng | en_US |
Publisher | Elsevier | en_US |
Rights | open access | en_US |
Subject in Portuguese | Leucemia mielóide aguda | en_US |
Subject in Portuguese | Células-tronco de leucemia | en_US |
Subject in Portuguese | Estresse oxidativo | en_US |
Title | Emerging drugs targeting cellular redox homeostasis to eliminate acute myeloid leukemia stem cells | en_US |
Type | Article | en_US |
DOI | 10.1016/j.redox.2023.102692 | |
Abstract | Acute myeloid leukemia (AML) is a very heterogeneous group of disorders with large differences in the percentage of immature blasts that presently are classified according to the specific mutations that trigger malignant proliferation among thousands of mutations reported thus far. It is an aggressive disease for which few targeted therapies are available and still has a high recurrence rate and low overall survival. The main reason for AML relapse is believed to be due to leukemic stem cells (LSCs) that have unlimited self-renewal capacity and long residence in a quiescent state, which promote greater resistance to traditional therapies for this cancer. AML LSCs have low oxidative stress levels, which appear to be caused by a combination of low mitochondrial activity and high activity of ROS-removing pathways. In this sense, oxidative stress has been thought to be an important new potential target for the treatment of AML patients, targeting the eradication of AML LSCs. The aim of this review is to discuss some drugs that induce oxidative stress to direct new goals for future research focusing on redox imbalance as an effective strategy to eliminate AML LSCs. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Odontologia. Departamento de Propedêutica. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Subject | Acute myeloid leukemia | en_US |
Subject | Leukemia stem cells | en_US |
Subject | Oxidative stress | en_US |
DeCS | Leucemia Mieloide Aguda | en_US |
DeCS | Células-Tronco | en_US |
DeCS | Estresse Oxidativo | en_US |