| Author | Hitchcock, Nicole Marie | |
| Author | Nunes, Danielle Devequi Gomes | |
| Author | Shiach, Job | |
| Author | Hodel, Katharine Valeria Saraiva | |
| Author | Barbosa, Josiane Dantas Viana | |
| Author | Rodrigues, Leticia Alencar Pereira | |
| Author | Coler, Brahm Seymour | |
| Author | Soares, Milena Botelho Pereira | |
| Author | Badaró, Roberto | |
| Access date | 2023-06-05T16:53:29Z | |
| Available date | 2023-06-05T16:53:29Z | |
| Document date | 2023 | |
| Citation | HITCHCOCK, Nicole Marie et al. Current Clinical Landscape and Global Potential of Bacteriophage Therapy. Viruses, v. 15, n. 4, p. 1-36, 2023. | en_US |
| ISSN | 1999-4915 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/58927 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). | en_US |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Bacteriófagos | en_US |
| Subject in Portuguese | Resistência antimicrobiana | en_US |
| Subject in Portuguese | Terapia fágica | en_US |
| Subject in Portuguese | Revisão | en_US |
| Title | Current clinical landscape and global potential of bacteriophage therapy | en_US |
| Type | Article | en_US |
| DOI | 10.3390/v15041020 | |
| Abstract | In response to the global spread of antimicrobial resistance, there is an increased demand for novel and innovative antimicrobials. Bacteriophages have been known for their potential clinical utility in lysing bacteria for almost a century. Social pressures and the concomitant introduction of antibiotics in the mid-1900s hindered the widespread adoption of these naturally occurring bactericides. Recently, however, phage therapy has re-emerged as a promising strategy for combatting antimicrobial resistance. A unique mechanism of action and cost-effective production promotes phages as an ideal solution for addressing antibiotic-resistant bacterial infections, particularly in lower- and middle-income countries. As the number of phage-related research labs worldwide continues to grow, it will be increasingly important to encourage the expansion of well-developed clinical trials, the standardization of the production and storage of phage cocktails, and the advancement of international collaboration. In this review, we discuss the history, benefits, and limitations of bacteriophage research and its current role in the setting of addressing antimicrobial resistance with a specific focus on active clinical trials and case reports of phage therapy administration. | en_US |
| Affilliation | School of Medicine. University of Missouri. Columbia, MO, USA. | en_US |
| Affilliation | Centro Universitário SENAI/CIMATEC. Instituto SENAI de Inovação (ISI) em Sistemas Avançados em Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | School of Medicine. University of California San Diego. San Diego, CA, USA. | en_US |
| Affilliation | Centro Universitário SENAI/CIMATEC. Instituto SENAI de Inovação (ISI) em Sistemas Avançados em Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Centro Universitário SENAI/CIMATEC. Instituto SENAI de Inovação (ISI) em Sistemas Avançados em Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Centro Universitário SENAI/CIMATEC. Instituto SENAI de Inovação (ISI) em Sistemas Avançados em Saúde. Salvador, BA, Brasil. | en_US |
| Affilliation | Elson S. Floyd College of Medicine. Washington State University. Spokane, WA, USA. | en_US |
| Affilliation | Centro Universitário SENAI/CIMATEC. Instituto SENAI de Inovação (ISI) em Sistemas Avançados em Saúde. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Centro Universitário SENAI/CIMATEC. Instituto SENAI de Inovação (ISI) em Sistemas Avançados em Saúde. Salvador, BA, Brasil. | en_US |
| Subject | Bacteriophages | en_US |
| Subject | Antimicrobial resistance | en_US |
| Subject | Phage therapy | en_US |
| Subject | Review | en_US |
| DeCS | Bacteriófagos | en_US |
| DeCS | Terapia por fagos | en_US |
| DeCS | Revisão | en_US |
