Author | Rodrigues, Júlia H.V. | |
Author | Carvalho, Alexandre B. de | |
Author | Silva, Valdenizia R. | |
Author | Santos, Luciano de S. | |
Author | Soares, Milena B. P. | |
Author | Bezerra, Daniel P. | |
Author | Oliveira, Katia M. | |
Author | Corrêa, Rodrigo S. | |
Access date | 2023-06-15T13:21:46Z | |
Available date | 2023-06-15T13:21:46Z | |
Document date | 2023 | |
Citation | RODRIGUES, Júlia H. V. et al. Copper (II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells. Polyhedron, v. 239, p. 1-8, 2023. | en_US |
ISSN | 1873-3719 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59039 | |
Sponsorship | Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG).
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Universidade Federal de Ouro Preto (UFOP). | en_US |
Language | eng | en_US |
Publisher | Elsevier | en_US |
Rights | open access | en_US |
Subject in Portuguese | Cobre(II) | en_US |
Subject in Portuguese | Diimines | en_US |
Subject in Portuguese | 2-hidroxibenzofenonas | en_US |
Subject in Portuguese | heteroléptico | en_US |
Subject in Portuguese | DNA | en_US |
Subject in Portuguese | BSA | en_US |
Title | Copper(II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells | en_US |
Type | Article | en_US |
DOI | 10.1016/j.poly.2023.116431 | |
Abstract | Here, we report four new heteroleptic Cu(II) complexes with the formula [Cu(bipy)(2H4MeBz)]NO3 (1), [Cu(phen)(2H4MeBz)]NO3 (2), [Cu(bipy)(2H4OcBz)]NO3 (3) and [Cu(phen)(2H4OcBz)]NO3 (4), where the ligands are 2-hydroxy-4-methoxybenzophenone (2H4MeBz), 2-hydroxy-4-(octyloxy)benzophenone (2H4OcBz), 2,2′-bipiridine (bipy) and 1,10-phenantroline (phen). All compounds present two bidentate ligands, a monoanionic 2-hydroxybenzophenone, forming a six-membered chelate ring and the diiminic ring forming a five-membered chelate ring, as well as one nitrate as counterion located at the axial position, as suggested by the crystal structure of complex 2. Complex/DNA interaction studies were also performed using spectroscopic titration (Kb close to 104 M−1), viscosity, Hoechst 33258 competition, and circular dichroism, revealing a moderate interaction between them. Additionally, complexes 1–4 moderately interact with BSA (Bovine Serum Albumin). The compounds were evaluated against HCT116 (human colon carcinoma) and HepG2 (human hepatocellular carcinoma) cancer cells and against MRC-5 (human lung fibroblast), a noncancer cells. The cytotoxic results suggest that complexes 2 and 4 are more cytotoxic than 1 and 3, showing that the presence of phen ligand may play an important role in increasing the biological effect of the compounds. | en_US |
Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Química. Campus Morro do Cruzeiro. Preto, MG, Brasil. | en_US |
Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Química. Campus Morro do Cruzeiro. Preto, MG, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Química. Campus Morro do Cruzeiro. Preto, MG, Brasil / SENAI CIMATEC. Instituto SENAI de Inovação em Sistemas Avançados de Saúde. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade de Brasília. Instituto de Química. Campus Darcy Ribeiro. Brasília, DF, Brasil. | en_US |
Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Química. Campus Morro do Cruzeiro. Preto, MG, Brasil. | en_US |
Subject | Copper(II) | en_US |
Subject | Diimines | en_US |
Subject | 2-Hydroxybenzophenones | en_US |
Subject | Heteroleptic | en_US |
Subject | DNA | en_US |
Subject | BSA | en_US |
DeCS | Cobre | en_US |
DeCS | DNA | en_US |