Author | Vialle, Emiliano Neves | |
Author | Fracaro, Letícia | |
Author | Barchiki, Fabiane | |
Author | Dominguez, Alejandro Correa | |
Author | Arruda, André de Oliveira | |
Author | Olandoski, Marcia | |
Author | Brofman, Paulo Roberto Slud | |
Author | Rebelatto, Carmen Lúcia Kuniyoshi | |
Access date | 2023-06-20T16:17:37Z | |
Available date | 2023-06-20T16:17:37Z | |
Document date | 2023 | |
Citation | VIALLE, Emiliano Neves et al. Human adipose-derived stem cells reduce cellular damage after experimental spinal cord injury in rats. Biomedicines, v. 11, n. 1394, p. 1-14, 2023. | en_US |
ISSN | 2227-9059 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59087 | |
Language | por | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Title | Human adipose-derived stem cells reduce cellular damage after experimental spinal cord injury in rats | en_US |
Type | Article | en_US |
Abstract | Traumatic spinal cord injury (SCI) is a devastating condition without an effective therapy. Cellular therapies are among the promising treatment strategies. Adult stem cells, such as mesenchymal stem cells, are often used clinical research for their immunomodulatory and regenerative potential. This study aimed to evaluate the effect of human adipose tissue-derived stem cells (ADSC) infusion through the cauda equina in rats with SCI. The human ADSC from bariatric surgery was isolated, expanded, and characterized. Wistar rats were subjected to blunt SCI and were divided into four groups. Two experimental groups (EG): EG1 received one ADSC infusion after SCI, and EG2 received two infusions, the first one after SCI and the second infusion seven days after the injury. Control groups (CG1 and CG2) received infusion with a culture medium. In vivo, cell tracking was performed 48 h and seven days after ADSC infusion. The animals were followed up for 40 days after SCI, and immunohistochemical quantification of myelin, neurons, and astrocytes was performed. Cellular tracking showed cell migration towards the injury site. ADSC infusion significantly reduced neuronal loss, although it did not prevent the myelin loss or enhance the area occupied by astrocytes compared to the control group. The results were similar when comparing one or two cell infusions. The injection of ADSC distal to the injured area was shown to be a safe and effective method for cellular administration in spinal cord injury. | en_US |
Affilliation | Pontifícia Universidade Católica do Paraná. Hospital Universitário do Cajuru. Grupo de Cirurgia da Coluna. Curitiba, PR, Brasil. | en_US |
Affilliation | Pontifícia Universidade Católica do Paraná. Escola de Medicina e Ciências da Vida. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Pontifícia Universidade Católica do Paraná. Escola de Medicina e Ciências da Vida. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil. | en_US |
Affilliation | Pontifícia Universidade Católica do Paraná. Hospital Universitário do Cajuru. Grupo de Cirurgia da Coluna. Curitiba, PR, Brasil. | en_US |
Affilliation | Pontifícia Universidade Católica do Paraná. Escola de Medicina. Departamento de Bioestatística. Curitiba, PR, Brasil. | en_US |
Affilliation | Pontifícia Universidade Católica do Paraná. Escola de Medicina e Ciências da Vida. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Pontifícia Universidade Católica do Paraná. Escola de Medicina e Ciências da Vida. Núcleo de Tecnologia Celular. Curitiba, PR, Brasil. / Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | Spinal Cord Injuries | en_US |
Subject | Cell Therapy | en_US |
Subject | Adipose Tissue | en_US |
Subject | Neurological Rehabilitation | en_US |
Subject | Animal Experimentation | en_US |
Subject in Spanish | Traumatismos de la Médula Espinal | en_US |
Subject in Spanish | Tejido Adiposo | en_US |
Subject in Spanish | Rehabilitación Neurológica | en_US |
Subject in Spanish | Experimentación Animal | en_US |
Subject in French | Traumatismes de la moelle épinière | en_US |
Subject in French | Thérapie cellulaire et tissulaire | en_US |
Subject in French | Tissu adipeux | en_US |
Subject in French | Rééducation neurologique | en_US |
Subject in French | Expérimentation animale | en_US |
DeCS | Traumas da Medula Espinhal | en_US |
DeCS | Terapia Celular | en_US |
DeCS | Tecido Adiposo | en_US |
DeCS | Reabilitação Neurológica | en_US |
DeCS | Experimentação Animal | en_US |