| Author | Sant’Anna, Thaís B. | |
| Author | Araujo, Natalia M. | |
| Access date | 2023-06-21T13:19:24Z | |
| Available date | 2023-06-21T13:19:24Z | |
| Document date | 2023 | |
| Citation | Sant`Anna, Thaís; ARAUJO, Natália M. Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics. Microorganisms, v. 11, 1101, p. 1- 14, Apr. 2023. | en_US |
| ISSN | 2076-2607 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59096 | |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | |
| Subject in Portuguese | Vírus da Hepatite B | en_US |
| Subject in Portuguese | Genótipo D | en_US |
| Subject in Portuguese | Subgenótipos | en_US |
| Subject in Portuguese | Distribuição Geográfica | en_US |
| Subject in Portuguese | Mutações | en_US |
| Subject in Portuguese | Evolução | en_US |
| Title | Hepatitis B Virus Genotype D: An Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics | en_US |
| Type | Article | |
| DOI | 10.3390/ microorganisms11051101 | |
| Abstract | The hepatitis B virus (HBV) genotype D (HBV/D) is the most extensively distributed
genotype worldwide with distinct molecular and epidemiological features. This report provides an
up-to-date review on the history of HBV/D subgenotyping and misclassifications, along with largescale
analysis of over 1000 HBV/D complete genome sequences, with the aim of gaining a thorough
understanding of the global prevalence and geographic distribution of HBV/D subgenotypes. We
have additionally explored recent paleogenomic findings, which facilitated the detection of HBV/D
genomes dating back to the late Iron Age and provided new perspectives on the origins of modern
HBV/D strains. Finally, reports on distinct disease outcomes and responses to antiviral therapy
among HBV/D subgenotypes are discussed, further highlighting the complexity of this genotype
and the importance of HBV subgenotyping in the management and treatment of hepatitis B. | en_US |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Virologia Molecular e Parasitologia. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Virologia Molecular e Parasitologia. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Hepatitis B virus | en_US |
| Subject | Genotype D | en_US |
| Subject | Subgenotypes | en_US |
| Subject | Geographic distribution | en_US |
| Subject | Mutations | en_US |
| Subject | Evolution | en_US |
