| Author | Pacífico, Lucila Grossi Gonçalves | |
| Author | Marinho, Fábio Antônio Vitarelli | |
| Author | Fonseca, Cristina Toscano | |
| Author | Barsante, Michele Mendes | |
| Author | Pinho, Vanessa | |
| Author | Sales Junior, Policarpo Ademar | |
| Author | Cardoso, Luciana S. | |
| Author | Araújo, Maria Ilma | |
| Author | Carvalho, Edgar M. | |
| Author | Cassali, Geovanni Dantas | |
| Author | Teixeira, Mauro Martins | |
| Author | Oliveira, Sergio Costa | |
| Access date | 2023-06-29T16:18:32Z | |
| Available date | 2023-06-29T16:18:32Z | |
| Document date | 2009 | |
| Citation | PACÍFICO, Lucila Grossi Gonçalves et al. Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10. Infect Immun., v. 77, n. 1, p. 98-107, 2009. doi: 10.1128/IAI.00783-07. | en_US |
| ISSN | 0019-9567 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59255 | |
| Language | eng | en_US |
| Publisher | American Society For Microbiology | en_US |
| Rights | restricted access | |
| Title | Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+CD25+Foxp3+ T cells independent of IL-10 | en_US |
| Type | Article | |
| DOI | 10.1128/IAI.00783-07 | |
| Abstract | In areas where schistosomiasis is endemic, a negative correlation is observed between atopy and helminth infection, associated with a low prevalence of asthma. We investigated whether Schistosoma mansoni infection or injection of parasite eggs can modulate airway allergic inflammation in mice, examining the mechanisms of such regulation. We infected BALB/c mice with 30 S. mansoni cercariae or intraperitoneally injected 2,500 schistosome eggs, and experimental asthma was induced by ovalbumin (OVA). The number of eosinophils in bronchoalveolar lavage fluid was higher in the asthmatic group than in asthmatic mice infected with S. mansoni or treated with parasite eggs. Reduced Th2 cytokine production, characterized by lower levels of interleukin-4 (IL-4), IL-5, and immunoglobulin E, was observed in both S. mansoni-treated groups compared to the asthmatic group. There was a reduction in the number of inflammatory cells in lungs of S. mansoni-infected and egg-treated mice, demonstrating that both S. mansoni infection and the egg treatment modulated the lung inflammatory response to OVA. Only allergic animals that were treated with parasite eggs had increased numbers of CD4+ CD25+ Foxp3+ T cells and increased levels of IL-10 and decreased production of CCL2, CCL3, and CCL5 in the lungs compared to the asthmatic group. Neutralization of IL-10 receptor or depletion of CD25+ T cells in vivo confirmed the critical role of CD4+ CD25+ Foxp3+ regulatory T cells in experimental asthma modulation independent of IL-10. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia e Instituto para Investigação em Imunologia-Instituto Milênio. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia e Instituto para Investigação em Imunologia-Instituto Milênio. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia e Instituto para Investigação em Imunologia-Instituto Milênio. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil, | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia e Instituto para Investigação em Imunologia-Instituto Milênio. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Hospital Santa Casa de Misericórdia de Belo Horizonte. Núcleo de Pós-Graduação e Pesquisa. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, Bahia, Brazil | en_US |
| Affilliation | Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, Bahia, Brazil | en_US |
| Affilliation | Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, Bahia, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia e Instituto para Investigação em Imunologia-Instituto Milênio. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia e Instituto para Investigação em Imunologia-Instituto Milênio. Belo Horizonte, MG, Brazil | en_US |
| Embargo date | 2030-12-31 | |
