| Author | Starling, Ana Lucia Borges | |
| Author | Martins Filho, Olindo Assis | |
| Author | Lambertucci, José Roberto | |
| Author | Labanca, Ludimila | |
| Author | Pereira, Silvio Roberto de Souza | |
| Author | Carvalho, Andréa Teixeira | |
| Author | Martins, Marina Lobato | |
| Author | Ribas, João Gabriel | |
| Author | Proietti, Anna Bárbara de Freitas Carneiro | |
| Author | Goncalves, Denise Utsch | |
| Access date | 2023-06-30T11:53:26Z | |
| Available date | 2023-06-30T11:53:26Z | |
| Document date | 2013 | |
| Citation | STARLING, Ana Lúcia Borges et al. Proviral load and the balance of serum cytokines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Acta Trop., v. 125, n. 1, p. 75-81, 2013. doi: 10.1016/j.actatropica.2012.09.012. | en_US |
| ISSN | 0001-706X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59290 | |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | restricted access | |
| Title | Proviral load and the balance of serum cytocines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) | en_US |
| Type | Article | |
| DOI | 10.1016/j.actatropica.2012.09.012 | |
| Abstract | This study compared the proviral load and the plasma cytokine profiles (interleukin-IL-2, IL-4, IL-6, IL-10, TNF-alpha, IFN-gamma) in 87 HTLV-1-infected individuals, including 28 with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), 32 with possible pHAM/TSP and 27 asymptomatic carriers (AC). The control group was composed by 21 HTLV-1-seronegative individuals. Our finding demonstrated that HAM/TSP group presented higher proviral load as compared to all other HTLV-1 groups (p < 0.0001). The HAM/TSP group showed higher serum concentration of IL-6 (p = 0.0009) as compared to all other groups. Moreover, higher serum concentration of IFN-gamma (p=0.0118) and IL-4 (p=0.0166) were observed in HAM/TSP group as compared to the healthy controls. Additionally, the HAM/TSP group also showed higher serum concentration of TNF-alpha (p = 0.0239) and IFN-gamma (p = 0.0118) as compared to AC. No differences in the serum concentration of IL-2 and IL-10 were observed among the groups. The analysis of cytokine balance demonstrated that HAM/TSP presented higher pro-inflammatory profile with enhanced IFN-gamma/IL-10 and IFN-gamma/IL-4 ratio as compared to AC and pHAM/TSP. Further analysis pointed out to a positive correlation between the IFN-gamma response and the proviral load in AC. Conversely, a negative association between TNE-alpha and IL-2 with the proviral load was the hallmark of HAM/TSP group. These findings suggested that the proviral load and the pro-inflammatory cytokine profile may be independent events in the peripheral blood of HAM/TSP individuals. The knowledge about the existence of individual virological/immunological behavior upon HTLV-1 infection, may guide to the establishment of more effective therapeutic interventions. (C) 2012 Elsevier B.V. All rights reserved | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Estado de Minas Gerais. Fundacão Centro de Hematologia e Hemoterapia de Minas Gerais. Belo Horizonte, MGs, Brazil | en_US |
| Affilliation | Hospital Sarah Kubitschek. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Estado de Minas Gerais. Fundacão Centro de Hematologia e Hemoterapia de Minas Gerais. Belo Horizonte, MG, Brazil/Faculdade da Saúde e Ecologia Humana. Vespasiano, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduacão em Infectologia e Medicina Tropical Minas Gerais. Belo Horizonte, MG, Brazil | en_US |
| Subject | HTLV-1 | en_US |
| Subject | HAM/TSP | en_US |
| Subject | Proviral load | en_US |
| Subject | Cytokine | en_US |
| Embargo date | 2099-12-31 | |
