Author | Filho Barreto, J. B. | |
Author | Marques Junior, Antonio de Pinho | |
Author | Golgher, Romain Rolland | |
Author | Lopes, E. | |
Author | Carvalho, P. H. A. | |
Author | Rossi, R. O. D. S. | |
Access date | 2023-07-03T18:37:55Z | |
Available date | 2023-07-03T18:37:55Z | |
Document date | 2007 | |
Citation | BARRETO FILHO, J. B. et al. Antiviral activity of bovine uterus and placenta induced by Newcastle disease virus Atividade antiviral do útero e da placenta bovina induzida pelo vírus da doença de Newcastle. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 59, n. 3, p. 586-590, 2007. | en_US |
ISSN | 0102-0935 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59370 | |
Language | eng | en_US |
Publisher | Universidade Federal de Minas Gerais | en_US |
Rights | open access | en_US |
Title | Antiviral activity of bovine uterus and placenta induced by Newcastle disease virus | en_US |
Type | Article | en_US |
DOI | 10.1590/S0102-09352007000300006 | |
Abstract | The antiviral activity profile of the uterus and fetal membranes from bovine placenta, induced by the Newcastle disease virus (NDV) throughout gestation, was investigated. Explants of the endometrium and caruncles were collected from the uterus, and amniochorion, allantochorion and cotyledons, from fetal placenta. Tissue cultures were induced with similar to 6.0 hemagglutinating units (RU) of NDV. Supernatants were concentrated 20 fold, filtered in 100kDa cut-off membranes and antiviral activity was titrated in MDBK x VSV system. Tissues of the uterus did not exhibit antiviral activity, while allantochorion and amniochorion produced antiviral factors throughout gestation. Antiviral factors were not related with IFN-alpha, gamma, tau or TNF-alpha. The antiviral activity pattern observed showed to be related with the development of fetal membranes and increased at the end of pregnancy. Such data suggest that IFN genes inducible by virus are present in fetal membranes of the cow placenta and their expression is dependent on the age of gestation. | en_US |
Affilliation | Universidade Federal de Lavras. Departamento de Medicina Veterinária. Lavras, MG, Brazil. | en_US |
Affilliation | Universidade Federal de Minas Gerais. Escola de Veterinária. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Universidade Federal de Lavras. Departamento de Medicina Veterinária. Lavras, MG, Brazil. | en_US |
Affilliation | Universidade Federal de Lavras. Departamento de Medicina Veterinária. Lavras, MG, Brazil. | en_US |
Affilliation | Universidade Federal de Lavras. Departamento de Medicina Veterinária. Lavras, MG, Brazil. | en_US |
Subject | Cattle | en_US |
Subject | Interferon | en_US |
Subject | Placenta | en_US |