| Author | Felizardo, Tania C. | |
| Author | Elsas, Maria Ignez Capella Gaspar | |
| Author | Lima, Gloria M. C. A. | |
| Author | Abrahamsohn, Ises de Almeida | |
| Access date | 2012-12-07T16:33:46Z | |
| Available date | 2012-12-07T16:33:46Z | |
| Document date | 2012 | |
| Citation | FELIZARDO, Tania C. Lack of signaling by IL-4 or by IL-4/IL-13 has more attenuating effects on Leishmania amazonensis dorsal skin – than on footpad-infected mice. Experimental Parasitology, New York, v. 130, n. 1, p. 48-57, jan. 2012. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/5937 | |
| Description | We thank Paulo B. Albe for assistance with tissue preparation
for immunohistochemistry and Miriam E. Mossoba and James C.
Wang for the manuscript correction. | pt_BR |
| Sponsorship | FAPESP, CNPq | pt_BR |
| Language | eng | pt_BR |
| Publisher | Academic Press | pt_BR |
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| Rights | restricted access | |
| Title | Lack of signaling by IL-4 or by IL-4/IL-13 has more attenuating effects on Leishmania amazonensis dorsal skin – than on footpad-infected mice | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.exppara.2011.09.015 | |
| Abstract | Lesion development in tegumentary leishmaniasis is markedly influenced by the inoculation site and the
type and number of injected infective forms. This and the yet unclear contribution of Th2 cytokines as
susceptibility factors to Leishmania amazonensis infection prompted us to investigate the roles of IL-4,
IL-13 and IL-10 on C57BL/6 and BALB/c mice infected in the footpad (paw) or rump with low-dose L. amazonensis purified-metacyclics. Wild-type (WT) mice of either strain developed, in the rump, a single large
ulcerated lesion whereas paw lesions never ulcerated and were much smaller in C57BL/6 than in BALB/c
mice. However, rump-inoculated IL-4-deficient (IL-4
/
) C57BL/6 mice did not develop any visible lesions
although parasites remained in the dermis and lymph nodes, even after systemic IL-10-receptor blocking.
By comparison, all IL-4
/
BALB/c mice developed rump ulcers. Strikingly, only 30% of rump-infected
IL-4Ra /
BALB/c mice developed lesions. IL-4
/
mice had higher IFN-c and lower IL-10 and IL-13 levels
than WT mice. Paw-infected IL-4Ra /
BALB/c mice developed minimal paw lesions. While other factors
contributing to L. amazonensis susceptibility cannot be discounted, our results indicate that absent signalling by IL-4 or by IL-4/IL-13 have more intense attenuating effects on rump than on paw lesions but do
not eradicate parasitism. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biomédicas IV. Departamento de Imunologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biomédicas IV. Departamento de Imunologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biomédicas IV. Departamento de Imunologia. São Paulo, SP, Brasil | pt_BR |
| Subject | IL-4 | pt_BR |
| Subject | IL-13 | pt_BR |
| Subject | Leishmania Amazonensis | pt_BR |
| Subject | IL-4 Receptor Alpha | pt_BR |
| DeCS | Interleucina-4 | pt_BR |
| DeCS | Interleucina-13 | pt_BR |
| DeCS | Leishmania | pt_BR |
| DeCS | Receptores de Interleucina-4 | pt_BR |
