| Author | Giunchetti, Denise da Silveira Lemos | |
| Author | Silva, Matheus Fernandes Costa | |
| Author | Silveira, Amanda Cardoso de Oliveira | |
| Author | Batista, Mauricio Azevedo | |
| Author | Oliveira-Fraga, Lúcia Alves | |
| Author | Silveira, Alda Maria Soares | |
| Author | Alvarez, Maria Carolina Barbosa | |
| Author | Martins Filho, Olindo Assis | |
| Author | Gazzinelli, Giovanni | |
| Author | Oliveira, Rodrigo Corrêa de | |
| Author | Carvalho, Andréa Teixeira de | |
| Access date | 2023-07-04T12:19:30Z | |
| Available date | 2023-07-04T12:19:30Z | |
| Document date | 2013 | |
| Citation | GIUNCHETTi, Denise da Silveira Lemos et al. Cytokine Pattern of T Lymphocytes in Acute Schistosomiasis mansoni Patients following Treated Praziquantel Therapy. Journal of Parasitology Research, v. 2013, p. 1-13, 2013. | en_US |
| ISSN | 2090-0031 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59390 | |
| Language | eng | en_US |
| Publisher | Hindawi Pub. Corp. | en_US |
| Rights | restricted access | |
| Title | Cytokine pattern of T lymphocytes in acute schistosomiasis mansoni patients following treated praziquantel therapy | en_US |
| Type | Article | |
| DOI | 10.1155/2013/909134 | |
| Abstract | Acute schistosomiasis is associated with a primary exposure and is more commonly seen in nonimmune individuals traveling through endemic regions. In this study, we have focused on the cytokine profile of T lymphocytes evaluated in circulating leukocytes of acute Schistosomiasis mansoni-infected patients (ACT group) before and after praziquantel treatment (ACT-TR group). Our data demonstrated increased values of total leukocytes, eosinophils, and monocytes in both groups. Interestingly, we have observed that patients treated with praziquantel showed increased values of lymphocytes as compared with noninfected group (NI) or ACT groups. Furthermore, a decrease of neutrophils in ACT-TR was observed when compared to ACT group. Analyses of short-term in vitro whole blood stimulation demonstrated that, regardless of the presence of soluble Schistosoma mansoni eggs antigen (SEA), increased synthesis of IFN-γ and IL-4 by T-cells was observed in the ACT group. Analyses of cytokine profile in CD8 T cells demonstrated higher percentage of IFN-γ and IL-4 cells in both ACT and ACT-TR groups apart from increased percentage of IL-10 cells only in the ACT group. This study is the first one to point out the relevance of CD8 T lymphocytes in the immune response induced during the acute phase of schistosomiasis. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Imunologia e Genômica de Parasitos. Belo Horizonte, MG, Brazil / Universidade Federal de Ouro Preto. Instituto de Ciências Biológicas. Laboratório de Imunoparasitologia. Ouro Preto, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas René. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Biológicas. Laboratório de Imunoparasitologia. Ouro Preto, MG, Brazil. | en_US |
| Affilliation | Universidade Vale do Rio Doce. Faculdade de Ciências da Saúde. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, Brazil. | en_US |
| Affilliation | Universidade Vale do Rio Doce. Faculdade de Ciências da Saúde. Núcleo de Pesquisa em Imunologia. Governador Valadares, MG, Brazil. | en_US |
| Affilliation | Santa Casa de Misericórdia de Belo Horizonte. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil. | en_US |
| Subject | Acute Schistosomiasis mansoni | |
| Subject | Lymphocytes T of Pattern C | |
| Subject | Praziquantel treatment (ACT-TR-Group) | |
| Subject | Schistosomiasis | |
| Subject | Tropical parasitic chronic disease | |
| Subject | Genus Schistosoma | |
| Embargo date | 2099-12-31 | |
