| Author | Andrade, Anderson Assunção | |
| Author | Varotti, Fernando de Pilla | |
| Author | Freitas, Isabela Oliveira de | |
| Author | Souza, Marcus Vinícius Nora de | |
| Author | Vasconcelos, Thatyana Rocha Alves | |
| Author | Boechat, Núbia | |
| Author | Krettli, Antoniana Ursine | |
| Access date | 2023-07-07T14:42:36Z | |
| Available date | 2023-07-07T14:42:36Z | |
| Document date | 2007 | |
| Citation | ANDRADE, Anderson Assunção e al. Enhanced activity of mefloquine and artesunic acid against Plasmodium falciparum in vitro and P. berghei in mice by combination with ciprofloxacin. European Journal of Pharmacology, v. 558, n. 1-3, p. 194-198. | en_US |
| ISSN | 0014-2999 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59468 | |
| Language | eng | en_US |
| Publisher | Elsevier Science | en_US |
| Rights | restricted access | |
| Title | Enhanced activity of mefloquine and artesunic acid against Plasmodium falciparum in vitro and P-berghei in mice by combination with ciprofloxacin | en_US |
| Type | Article | |
| DOI | 10.1016/j.ejphar.2006.11.061 | |
| Abstract | The antimalarial activity of combinations of mefloquine or artesunic acid with ciprofloxacin and other synthetic fluoroquinolone was tested in vitro against Plasmodiumfalciparum using a strain (BHz26/86) partially resistant to chloroquine and a resistant clone (W2); both are sensitive to mefloquine. Inhibition of parasite growth was measured in relation to controls without drugs, either by counting parasitetma in Giernsa-stained blood smears or by measuring the reduction in [H-3]-hypoxanthine uptake. Combinations containing artesunic acid or mefloquine with ciprofloxacin had significant in vitro activity, inhibiting by more than 90% of the growth of both strains of P. falcipartun at doses significantly lower than those of the antimalarials alone. When tested in mice inoculated with P berghei chloroquine-sensitive parasites (NK65 strain), ciprofloxacin was inactive, whereas mefloquine and artesunic acid were active (IC50=2.5 and 4.2 mg/kg, respectively); combinations containing mefloquine at an equivalent dose of 0.5 mg/kg reduced parasitemia by 59% and artesunic acid activity was also improved by ciprofloxacin. Our data support the idea that ciprofloxacin in combination with antimalarials may be useful in the treatment of chloroquine-resistant human malaria, allowing the use of lower doses of these drugs. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malaria. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malaria. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malaria. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malaria. Belo Horizonte, MG, Brazil. | en_US |
| Subject | Mefloquine | en_US |
| Subject | Artesunic acid | en_US |
| Subject | Ciprofloxacin | en_US |
| Subject | Antimalarial activity | en_US |
| Embargo date | 2099-12-31 | |
