| Author | Filho, Anibal Basile | |
| Author | Rogerio, Alexandre de Paula | |
| Author | Malheiro, Adriana | |
| Author | Machado, Eleuza Rodrigues | |
| Author | Martins Filho, Olindo Assis | |
| Author | Andrade, Marileia Chaves | |
| Author | Soares, E. G. | |
| Author | Medeiros, Alexandra Ivo de | |
| Author | Faccioli, Lucia Helena | |
| Access date | 2023-07-11T19:20:48Z | |
| Available date | 2023-07-11T19:20:48Z | |
| Document date | 2007 | |
| Citation | BASILE FILHO, Anibal et al. Impact of MK886 on eosinophil counts and phenotypic features in toxocariasis. Scand J Immunol., v. 65, n. 4, p. 344-352, 2007. doi: 10.1111/j.1365-3083.2007.01911.x. | en_US |
| ISSN | 0300-9475 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59517 | |
| Language | eng | en_US |
| Publisher | Willey | en_US |
| Rights | restricted access | |
| Title | Impact of MK886 on eosinophil counts and phenotypic features in toxocariasis | en_US |
| Type | Article | |
| DOI | 10.1111/j.1365-3083.2007.01911.x | |
| Abstract | Experimental toxocariasis was used as a model of eosinophil migration. Mice inoculated with 200 Toxocara canis eggs were treated with the leukotriene inhibitor MK886 (1 mg/kg/day). Eosinophils were counted in peripheral blood (PB), peritoneal cavity (PC) and bronchoalveolar lavage fluid (BALF) samples on post-infection days 3, 6, 12, 18, 24 and 36. Eosinophil expression of Mac-1 and VLA-4 was analysed in PB and PC samples. We found that T. canis infection induced systemic eosinophilia from post-infection day 3, peaking on days 6, 12 and 24 in PB, PC and BALF samples respectively. Eosinophilia was more pronounced in PB and PC samples than in BALF samples, and MK886 downregulated eosinophilia to varying degrees in the different sample types. In PB and PC samples, T. canis infection caused early upregulation of Mac-1 with late changes in the VLA-4 profile, whereas MK886 had opposite effects. The distinct time-dependent eosinophilia peaks and differential involvement of leukotrienes in integrin expression demonstrate that, despite the systemic eosinophilia triggered by T. canis infection, inflammatory responses vary by compartment | en_US |
| Affilliation | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas. Departamento de Analises Clınicas, Toxicologicas e Bromatologicas. Ribeirao Preto, SP, Brasil | en_US |
| Affilliation | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas. Departamento de Analises Clınicas, Toxicologicas e Bromatologicas. Ribeirao Preto, SP, Brasil | en_US |
| Affilliation | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas. Departamento de Analises Clınicas, Toxicologicas e Bromatologicas. Ribeirao Preto, SP, Brasil | en_US |
| Affilliation | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas. Departamento de Analises Clınicas, Toxicologicas e Bromatologicas. Ribeirao Preto, SP, Brasil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade de Sao Paulo. Faculdade de Medicina. Departamento de Patologia. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas. Departamento de Analises Clınicas, Toxicologicas e Bromatologicas. Ribeirao Preto, SP, Brasil | en_US |
| Affilliation | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas. Departamento de Analises Clınicas, Toxicologicas e Bromatologicas. Ribeirao Preto, SP, Brasil | en_US |
| Embargo date | 2099-12-31 | |
