| Author | Marques, Fabiana K. | |
| Author | Nunes, Fernanda Freire Campos | |
| Author | Martins Filho, Olindo Assis | |
| Author | Carvalho, Andrea Teixeira | |
| Author | Dusse, Luci Maria Sant Ana | |
| Author | Gomes, Karina B. | |
| Access date | 2023-07-11T19:41:09Z | |
| Available date | 2023-07-11T19:41:09Z | |
| Document date | 2012 | |
| Citation | MARQUES, Fabiana Kalina et al. Circulating microparticles in severe preeclampsia. Clinica Chimica Acta, v. 414, p. 253-258, 2012. | en_US |
| ISSN | 0009-8981 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59518 | |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | restricted access | |
| Title | Circulating microparticles in severe preeclampsia | en_US |
| Type | Article | |
| DOI | 10.1016/j.cca.2012.09.023 | |
| Abstract | The present study aimed to evaluate microparticles (MPs) from different sources in women with severe preeclampsia (PE) compared with normotensive pregnant women and non-pregnant women. This case-control study evaluated 28 pregnant women with severe PE, 30 normotensive pregnant women, and 29 non-pregnant women. MPs from neutrophils, endothelial cells, monocytes, platelets, leukocytes, erythrocytes, and syncytiotrophoblast were evaluated using flow cytometry. A higher total number of MPs were observed in women with severe PE compared with normotensive pregnant women and non-pregnant women (P=0.004 and P=0.001, respectively). MPs derived from erythrocytes were increased in women with severe PE compared with normotensive pregnant women (P=0.002). A trend towards association was observed between platelet count and the number of MPs derived from platelets (P=0.09) in severe PE group. A positive correlation was also found between the number of endothelial cell-derived MPs and the number of platelet-derived MPs, leukocyte-derived MPs, neutrophil-derived MPs, and lymphocyte-derived MPs (P<0.05) in severe PE pregnant women. MP counts can be increased in severe PE, and erythrocyte and endothelial cell-derived MPs seem to be associated to severe PE. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brazil. | en_US |
| Subject | Coagulation | en_US |
| Subject | Inflammation | en_US |
| Subject | Microparticles | en_US |
| Subject | Preeclampsia | en_US |
| Embargo date | 2030-12-31 | |
