| Author | Codes, Liana | |
| Author | Freitas, Luiz Antonio Rodrigues de | |
| Author | Jesus, Rogério Santos | |
| Author | Vitvitski, Ludmila | |
| Author | Silva, Luciano Kalabric | |
| Author | Trépo, Christian | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Paraná, Raymundo | |
| Access date | 2012-12-10T19:25:14Z | |
| Available date | 2012-12-10T19:25:14Z | |
| Document date | 2003 | |
| Citation | CODES, L. et al. Comparative study of Hepatitis C virus genotypes 1 and 3 in Salvador, Bahia. Brazilian Journal of Infectious Disease, v. 7, n. 6, p. 409-417, dez. 2003. | pt_BR |
| ISSN | 0022-1899 | |
| URI | https://www.arca.fiocruz.br/handle/icict/5951 | |
| Language | eng | pt_BR |
| Rights | open access | |
| Title | Comparative study of Hepatitis C virus genotypes 1 and 3 in Salvador, Bahia | pt_BR |
| Type | Article | pt_BR |
| Abstract | Hepatitis C virus displays a high degree of genetic mutation, with considerable heterogeneity,
motivating clinical and biomolecular investigations. It is necessary to understand the effects of
genotypes on the course of the disease, as well as their peculiarities at the regional level. Objective:
The study objective was to compare epidemiological, biochemical and histological aspects of
hepatitis C virus genotypes 1 and 3 in Salvador, Bahia. Study Design: Data were collected
retrospectively from outpatient medical records. Materials and Methods: 127 patients with positive
anti-HCV results were selected, based on detectable RNA-HCV (RT-PCR) of genotypes 1a, 1b and
3a. Results: Thirty-nine (30.7%) individuals were infected by subtype 1a, 45 (35.4%) by subtype
1b and 43 (33.9%) by subtype 3a. Most (73.2%) patients were male, with an average age of 47.8
years. The subtype 1b-infected patients had the highest average age (512 ±11.17; P=0.09). The
use of illicit injected drugs was more frequent among subtype 3a infected individuals when compared
with genotype 1 (6/43; 14% and 3/84; 3.6%, respectively; P=0,06). No significant differences
were found for other epidemiological characteristics. Average values for GT, AST, ALT and ferritin
did not differ between the groups (64, 78, 109, 276, respectively). Thyroid dysfunction occurred in
7/30 (23.3%) of those infected by genotype 3 (P=0.05). Cryoglobulinemia was also more frequent
in this group (5/13, 38%, P=0.02). Most patients presented limited necro-inflammatory activity,
stages 2 and 3 by the METAVIR Classification. In some cases, dissociation was noticed between
inflammatory activity and fibrosis. No significant differences were found in the histopathological
findings of the various genotypes. Younger patients had a significantly smaller degree of necrosis
in stomatocytosis (P=0.032) and fibrosis (P=0.012). Intense parenchymatous activity and lymphoid
follicles were more frequent among alcohol consumers (P=0.06 and P=0.04, respectively).
Conclusions: In Bahia, genotype 3 dissemination seems to be associated with illicit drug use. The
disease evolution depends on a function of complex interactions between virus and host. Age and
alcohol consumption stand out as important variables in the development of cirrhosis. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Institut National de la Santé et de la Recherche Médicale. Lyon, France | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Institut National de la Santé et de la Recherche Médicale. Lyon, France | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Subject | Hepatitis C | pt_BR |
| Subject | Genotype | pt_BR |
| DeCS | Hepatite C/virologia | pt_BR |
| DeCS | Hepatite C/epidemiologia | pt_BR |
| DeCS | Hepatite C/transmissão | pt_BR |
| DeCS | Estudos Retrospectivos | pt_BR |
| DeCS | Reação em Cadeia da Polimerase Via Transcriptase | pt_BR |
| DeCS | Reversa | pt_BR |
| DeCS | Fatores de Risco | pt_BR |
| DeCS | Genótipo | pt_BR |
| DeCS | Brasil/epidemiologia | pt_BR |
| DeCS | Meia-Idade | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Idoso | pt_BR |
| DeCS | Adolescente | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Estudo Comparativo | pt_BR |
