| Author | Wethington, A. R. | |
| Author | Zavodna, M. | |
| Author | Smith, M. K. | |
| Author | Oliveira, Guilherme Corrêa de | |
| Author | Lewis, F. | |
| Author | Minchella, D. J. | |
| Access date | 2023-07-12T19:24:10Z | |
| Available date | 2023-07-12T19:24:10Z | |
| Document date | 2007 | |
| Citation | WETHINGTON, A. R. et al. Population genetic structure of Biomphalaria glabrata in a schistosomiasis-endemic region in Brazil. Journal of Molluscan Studies, v. 73, n. 1, p. 45–52, 2007. | en_US |
| ISSN | 1464-3766 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59542 | |
| Sponsorship | NATIONAL INSTITUTES OF HEALTH | en_US |
| Language | eng | en_US |
| Publisher | Oxford University Press | en_US |
| Rights | restricted access | |
| Title | Population genetic structure of Biomphalaria glabrata in a schistosomiasis-endemic region in Brazil | en_US |
| Type | Article | |
| DOI | 10.1093/mollus/eyl028 | |
| Abstract | The population genetic structure of the freshwater snail, Biomphalaria glabrala, was assessed in the municipality of Virgem das Gracas as (Minas Gerais, Brazil), a schistosomiasis-endemic area. The seven microsatellite loci that were used to genotype 326 individuals from 17 collection sites within a 3-km radius revealed high genetic variability. However, we found a deficit of heterozygotes relative to Hardy-Weinberg expectations for most of the loci and in many collection sites, indicating a high level of inbreeding. This may be the result of founder effects and sib-mating. A high level of overall population genetic differentiation among B. glabrala collection sites suggested low gene flow at this relatively small spatial scale in this region. However, subsequent analyses also indicated that these patterns may also result from founder events and that an exchange of individuals between particular collection sites does exist. The isolation-by-distance correlation between collection sites of B. glabrala was found to be significant. However, only approximately 6% of the variance in F-ST was explained by geographic distances suggesting that there are other factors affecting genetic differentiation among these collection sites. It is likely that the current population genetic structure reflects patterns of both migration and founder events. Results from this study are important for understanding the potential for local adaptation between schistosomes and their snail hosts at this epidemiologically relevant scale. | en_US |
| Affilliation | Biology Department. Chowan College. Murfreesboro, NC, USA. | en_US |
| Affilliation | Department of Biological Sciences. Purdue University. West Lafayette, IN, USA. | en_US |
| Affilliation | Department of Biological Sciences. Purdue University. West Lafayette, IN, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Biomedical Research Institute. Rockville, MD, USA. | en_US |
| Affilliation | Biomedical Research Institute. Rockville, MD, USA. | en_US |
| Subject | Population genetic | |
| Subject | Biomphalaria glabrata | |
| Subject | Schistosomiasis | |
| Subject | Endemic area | |
| Embargo date | 2099-12-31 | |
