| Author | Mattos, Ana Carolina Alves de | |
| Author | Pereira, Glauco de Carvalho | |
| Author | Passos, Liana konovaloff Jannotti | |
| Author | Kusel, John Robert | |
| Author | Coelho, Paulo Marcos Zech | |
| Access date | 2023-07-13T15:57:52Z | |
| Available date | 2023-07-13T15:57:52Z | |
| Document date | 2007 | |
| Citation | MATTOS, Ana Carolina Alves de et al. Evaluation of the effect of oxamniquine, praziquantel and a combination of both drugs on the intramolluscan phase of Schistosoma mansoni. Acta Tropica, v. 102, n. 2, p. 84-91, 2007. | en_US |
| ISSN | 1873-6254 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59565 | |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | restricted access | |
| Title | Evaluation of the effect of oxamniquine, praziquantel and a combination of both drugs on the intramolluscan phase of Schistosoma mansoni | en_US |
| Type | Article | |
| DOI | 10.1016/j.actatropica.2007.04.002 | |
| Abstract | The activity of oxamniquine (OXA), praziquantel (PZQ), and a combination of both drugs was evaluated at the intramolluscan phase of Schistosoma mansoni. Biomphalaria glabrata snails infected with S. mansoni were treated with 500 mg/kg OXA, 1000 mg/kg PZQ or with 250 mg/kg OXA and 500 mg/kg PZQ, in association, at the pre-patent and patent phases of infection. The results showed that either treatments with OXA or PZQ, alone, at the pre-patent period, delayed the parasite's development, increasing the pre-patent period by approximately 10 days. At the same pre-patent period, treatment with a combination of OXA/PZQ delayed the parasite's development even more, extending the pre-patent period up to 56 days. At the patent period, treatment with OXA and PZQ, alone, interrupted cercarial shedding. When the snails were treated with 1000 mg/kg PZQ, the cercarial production was re-established 15 days after treatment, but in lower numbers than those obtained before treatment, whereas the snails treated with 500 mg/kg OXA were able to shed cercariae in similar quantities to those observed before treatment. The association 250 mg/kg OXA + 500 mg/kg PZQ, at the patent period, not only discontinued cercarial shedding, but also led to the "cure" of the snails, showing a synergistic effect of this combination of drugs. These results suggest that this model will be useful for selection of resistant parasites, as well as for screening new anti schistosomal drugs. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Moluscário. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | University of Glasgow. Glasgow, Scotland, UK. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil / Santa Casa de Misericórdia. Belo Horizonte, MG, Brazil. | en_US |
| Subject | Schistosoma mansoni | en_US |
| Subject | Praziquantel | en_US |
| Subject | Oxamniquine | en_US |
| Subject | Synergistic effect | en_US |
| Subject | Intramolluscan phase | en_US |
| Embargo date | 2099-12-31 | |
