| Author | Bazzani, Liliana | |
| Author | Imperia, Elena | |
| Author | Scarpa, Fabio | |
| Author | Sanna, Daria | |
| Author | Casu, Marco | |
| Author | Borsetti, Alessandra | |
| Author | Pascarella, Stefano | |
| Author | Petrosillo, Nicola | |
| Author | Cella, Eleonora | |
| Author | Giovanetti, Marta | |
| Author | Ciccozzi, Massimo | |
| Access date | 2023-07-14T13:11:16Z | |
| Available date | 2023-07-14T13:11:16Z | |
| Document date | 2023 | |
| Citation | BAZZANI, Liliana et al. SARS-CoV CH.1.1 Variant: Genomic and Structural Insight. Infectious disease reports, v. 15, n. 3, p. 292-298, 2023. doi.org/10.3390/idr15030029. | en_US |
| ISSN | 2036-7430 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59592 | |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| Title | SARS-CoV CH.1.1 Variant: Genomic and Structural Insight | en_US |
| Type | Article | en_US |
| Abstract | In early February 2023, the Omicron subvariant XBB.1.5, also known as “Kraken”, accounted for more than 44% of new COVID-19 cases worldwide, whereas a relatively new Omicron subvariant named CH.1.1, deemed “Orthrus”, accounted for less than 6% of new COVID-19 cases during the subsequent weeks. This emerging variant carries a mutation, L452R, previously observed in the highly pathogenic Delta and the highly transmissible BA.4 and BA.5 variants, necessitating a shift to active surveillance to assure adequate preparedness for likely future epidemic peaks. We provide a preliminary understanding of the global distribution of this emerging SARS-CoV-2 variant by combining genomic data with structural molecular modeling. In addition, we shield light on the number of specific point mutations in this lineage that may have functional significance, thereby increasing the risk of disease severity, vaccine resistance, and increased transmission. This variant shared about 73% of the mutations with Omicron-like strains. Our homology modeling analysis revealed that CH.1.1 may have a weakened interaction with ACE2 and that its electrostatic potential surface appears to be more positive than that of the reference ancestral virus. Finally, our phylogenetic analysis revealed that this likely-emerging variant was already cryptically circulating in European countries prior to its first detection, highlighting the importance of having access to whole genome sequences for detecting and controlling emerging viral strains | en_US |
| Affilliation | Sciences and Technologies for Sustainable Development and One Health. University Campus Bio-Medico of Rome. Rome, Italy | en_US |
| Affilliation | Unit of Medical Statistics and Molecular Epidemiology. University Campus Bio-Medico of Rome. Rome, Italy/Unit of Gastroenterology. Department of Medicine. University Campus Bio-Medico of Rome. Rome, Italy | en_US |
| Affilliation | Department of Biomedical Sciences. University of Sassari. Sassari, Italy | en_US |
| Affilliation | Department of Biomedical Sciences. University of Sassari. Sassari, Italy | en_US |
| Affilliation | Department of Veterinary Medicine. University of Sassari. Sassari, Italy | en_US |
| Affilliation | National HIV/AIDS Research Center. National Institute of Health. Rome, Italy | en_US |
| Affilliation | Department of Biochemical Sciences “A. Rossi Fanelli”. Sapienza University of Rome, Rome, Italy | en_US |
| Affilliation | Infection Prevention and Control—Infectious Disease Service. Fondazione Policlinico Universitario Campus Bio-Medico. Rome, Italy | en_US |
| Affilliation | Burnett School of Biomedical Sciences. University of Central Florida. Orlando, FL, USA | en_US |
| Affilliation | Sciences and Technologies for Sustainable Development and One Health. University Campus Bio-Medico of Rome. Rome, Italy/Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Unit of Medical Statistics and Molecular Epidemiology. University Campus Bio-Medico of Rome. Rome, Italy | en_US |
| Subject | CH.1.1 variant | en_US |
| Subject | genomic surveillance | en_US |
| Subject | SARS-CoV-2 | en_US |
| Subject | mutational pattern profile | en_US |
