| Author | Fonseca, Fernanda L. | |
| Author | Reis, Flavia C. G. | |
| Author | Sena, Bianca A. G. | |
| Author | Jozefowicz, Luísa J. | |
| Author | Kmetzsch, Livia | |
| Author | Rodrigues, Marcio L. | |
| Access date | 2023-07-18T07:24:05Z | |
| Available date | 2023-07-18T07:24:05Z | |
| Document date | 2019 | |
| Citation | FONSECA, Fernanda L. et al. The overlooked glycan components of the cryptococcus capsule. Current Topics in Microbiology and Immunology, v. 422, p. 31-43, 2019. | en_US |
| ISSN | 0070-217X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59642 | |
| Language | eng | en_US |
| Publisher | Springer Verlag | en_US |
| Rights | restricted access | |
| MeSH | Animals | en_US |
| MeSH | Cell Wall | en_US |
| MeSH | Cryptococcosis | en_US |
| MeSH | Cryptococcus neoformans | en_US |
| MeSH | Humans | en_US |
| MeSH | Polysaccharides | en_US |
| MeSH | Virulence | en_US |
| Title | The overlooked glycan components of the cryptococcus capsule | en_US |
| Type | Article | |
| DOI | 10.1007/82_2018_140 | |
| Abstract | Pathogenic species of Cryptococcus kill approximately 200,000 people each year. The most important virulence mechanism of C. neoformans and C. gattii, the causative agents of human and animal cryptococcosis, is the ability to form a polysaccharide capsule. Acapsular mutants of C. neoformans are avirulent in mice models of infection, and extracellularly released capsular polysaccharides are deleterious to the immune system. The principal capsular component in the Cryptococcus genus is a complex mannan substituted with xylosyl and glucuronyl units, namely glucuronoxylomannan (GXM). The second most abundant component of the cryptococcal capsule is a galactan with multiple glucuronyl, xylosyl, and mannosyl substitutions, namely glucuronoxylomannogalactan (GXMGal). The literature about the structure and functions of these two polysaccharides is rich, and a number of comprehensive reviews on this topic are available. Here, we focus our discussion on the less explored glycan components associated with the cryptococcal capsule, including mannoproteins and chitin-derived molecules. These glycans were selected for discussion on the basis that i) they have been consistently detected not only in the cell wall but also within the cryptococcal capsular network and ii) they have functions that impact immunological and/or pathogenic mechanisms in the Cryptococcus genus. The reported functions of these molecules strongly indicate that the biological roles of the cryptococcal capsule go far beyond the well-known properties of GXM and GXMGal. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil. | en_US |
| Affilliation | Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia. Porto Alegre, RS, Brazil / Universidade Federal do Rio Grande do Sul, Porto Alegre. Departamento de Biologia Molecular e Biotecnologia. Porto Alegre, RS, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brazil / Cidade Industrial de Curitiba. Curitiba, PR, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Wheat-germ lectin | en_US |
| Subject | T-cell responses | en_US |
| Subject | Neoformans glucuronoxylomannan | en_US |
| Subject | Galactoxylomannan | en_US |
| Subject | Mannoprotein | en_US |
| Subject | Chitosan | en_US |
| e-ISSN | 2196-9965 | |
| Embargo date | 2030-12-31 | |
