| Autor | Scarpa, Fabio | |
| Autor | Imperia, Elena | |
| Autor | Ciccozzi, Alessandra | |
| Autor | Pascarella, Stefano | |
| Autor | Quaranta, Miriana | |
| Autor | Giovanetti, Marta | |
| Autor | Borsetti, Alessandra | |
| Autor | Petrosillo, Nicola | |
| Autor | Ciccozzi, Massimo | |
| Data de acesso | 2023-07-18T14:19:15Z | |
| Data de disponibilização | 2023-07-18T14:19:15Z | |
| Data do publicação | 2023 | |
| Citação | SCARPA, Fabio et al. Khosta: A Genetic and Structural Point of View of the Forgotten Virus. Infect Dis Rep, v. 15, n. 3, p. 307-318, 2023. doi.org/10.3390/idr15030031. | en_US |
| ISSN | 2036-7449 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59658 | |
| Idioma | eng | en_US |
| Editor | MDPI | en_US |
| Direito Autoral | open access | en_US |
| Título | Khosta: A Genetic and Structural Point of View of the Forgotten Virus | en_US |
| Tipo do documento | Article | en_US |
| Resumo em Inglês | Abstract: Bats are well-known to be natural reservoirs of various zoonotic coronaviruses, which have caused outbreaks of severe acute respiratory syndrome (SARS) and the COVID-19 pandemic in 2002 and 2019, respectively. In late 2020, two new Sarbecoviruses were found in Russia, isolated in Rhinolophus bats, i.e., Khosta-1 in R. ferrumequinum and Khosta-2 in R. hipposideros. The potential danger associated with these new species of Sarbecovirus is that Khosta-2 has been found to interact with the same entry receptor as SARS-CoV-2. Our multidisciplinary approach in this study demonstrates that Khosta-1 and -2 currently appear to be not dangerous with low risk of spillover, as confirmed by prevalence data and by phylogenomic reconstruction. In addition, the interaction between Khosta-1 and -2 with ACE2 appears weak, and furin cleavage sites are absent. While the possibility of a spillover event cannot be entirely excluded, it is currently highly unlikely. This research further emphasizes the importance of assessing the zoonotic potential of widely distributed batborne CoV in order to monitor changes in genomic composition of viruses and prevent spillover events (if any) | en_US |
| Afiliação | Department of Biomedical Sciences. University of Sassari. Sassari, Italy | en_US |
| Afiliação | Unit of Medical Statistics and Molecular Epidemiology. University of Campus Bio-Medico. Rome, Italy/Unit of Gastroenterology. Department of Medicine. University Campus Bio-Medico. Rome, Italy. | en_US |
| Afiliação | Unit of Gastroenterology. Department of Medicine. University Campus Bio-Medico. Rome, Italy. | en_US |
| Afiliação | Department of Biochemical Sciences "A. Rossi Fanelli". University of Rome "La Sapienza”. Rome, Italy. | en_US |
| Afiliação | Department of Biochemical Sciences "A. Rossi Fanelli". University of Rome "La Sapienza”. Rome, Italy. | en_US |
| Afiliação | Sciences and Technologies for Sustainable Development and One Health. University of Campus Bio-Medico of Rome. Rome, Italy/Rene Rachou. Fundação Oswaldo Cruz. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | National HIV/AIDS Research Center. Istituto Superiore di Sanità. Rome, Italy. | en_US |
| Afiliação | Infection Prevention and Control-Infectious Disease Service. Fondazione Policlinico Universitario Campus Bio-Medico. Rome, Italy. | en_US |
| Afiliação | Unit of Medical Statistics and Molecular Epidemiology. University of Campus Bio-Medico. Rome, Italy. | en_US |
| Palavras-chave em inglês | bat SARS-like coronaviruses | en_US |
| Palavras-chave em inglês | SARS-CoV-like viruses | en_US |
| Palavras-chave em inglês | horseshoe bats | en_US |
| Palavras-chave em inglês | Rhinolophus | en_US |
| Palavras-chave em inglês | khosta viruses | en_US |
| Palavras-chave em inglês | sarbecovirus | en_US |
| Palavras-chave em inglês | coronavirus | en_US |
| Palavras-chave em inglês | epidemiology | en_US |
| Palavras-chave em inglês | spillover | en_US |
