| Author | Ferraz, Karina Silva de Oliveira | |
| Author | Cardoso, Gabriele M.M. | |
| Author | Bertollo, Caryne Margotto | |
| Author | Fagundes, Elaine Maria de Souza | |
| Author | Speziali, Nivaldo | |
| Author | Zani, Carlos Leomar | |
| Author | Mendes, Isolda Castro | |
| Author | Gomes, Maria A. | |
| Author | Beraldo, Heloisa | |
| Access date | 2023-07-19T17:49:08Z | |
| Available date | 2023-07-19T17:49:08Z | |
| Document date | 2011 | |
| Citation | FERRAZ, Karina Silva de Oliveira et al. N(4)-tolyl-2-benzoylpyridine-derived thiosemicarbazones and their palladium(II) and platinum(II) complexes: Cytotoxicity against human solid tumor cells. Polyhedron, v. 30, n. 2, p. 315-321, 2011. doi.org/10.1016/j.poly.2010.10.014 | en_US |
| ISSN | 0277-5387 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59675 | |
| Language | eng | en_US |
| Publisher | Elsevier Ltd. | en_US |
| Rights | restricted access | |
| Subject in Portuguese | Thiosemicarbazones | en_US |
| Subject in Portuguese | Platinum(II) complexes | en_US |
| Subject in Portuguese | Solid tumor | en_US |
| Title | N(4)-tolyl-2-benzoylpyridine-derived thiosemicarbazones and their palladium(II) platinum(II) complexes: Cytotoxicity against human solid tumor cells | en_US |
| Type | Article | |
| DOI | 10.1016/j.poly.2010.10.014 | |
| Abstract | Complexes [Pt(2Bz4oT)Cl], [Pt(2Bz4mT)Cl], and [Pt(2Bz4pT)Cl] were prepared with N(4)-ortho-(H2Bz4oT), N(4)-meta-(H2Bz4mT), and N(4)-para-(H2Bz4pT) tolyl-2-benzoylpyridine-derived thiosemicarbazones. The thiosemicarbazones exhibited moderate anti-proliferative activity against HepG2 (hepatoma) and UACC-62 (melanoma) cancer cell lines, but showed high anti-proliferative effect against A431 (epithelial carcinoma) cancer cell lines. Upon coordination to platinum(II) the anti-proliferative activity decreases in all cases. The cytotoxicity of the previously prepared palladium(II) analogues [Pd(2Bz4oT)Cl], [Pd(2Bz4mT)Cl], and [Pd(2Bz4pT)Cl] was also investigated. As in the case of the platinum(II) complexes, coordination to palladium(II) did not lead to activity improvement. Investigations on the mechanism of cytotoxic action against A431 cells revealed that [Pd(2Bz4oT)Cl] induced DNA fragmentation and apoptosis while H2Bz4oT did not present this effect. The high anti-proliferative effect of the thiosemicarbazones and [Pd(2Bz4oT)Cl] against A431 cells, together with the pro-apoptotic effect of [Pd(2Bz4oT)Cl] suggests that these compounds have potential as chemotherapeutic drug candidates. (C) 2010 Elsevier Ltd. All rights reserved | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Física. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil | en_US |
| Subject | Thiosemicarbazones | en_US |
| Subject | Platinum(II) complexes | en_US |
| Subject | Solid tumor | en_US |
| Embargo date | 2099-12-31 | |
