| Author | Caetano, Braulia Costa | |
| Author | Biswas, Amlan | |
| Author | Lima-Junior, Djalma S. | |
| Author | Benevides, Luciana | |
| Author | Mineo, Tiago W.P. | |
| Author | Horta, Catarina V. | |
| Author | Lee, Kyoung-Hee | |
| Author | Silva, Joao S. | |
| Author | Gazzinelli, Ricardo Tostes | |
| Author | Zamboni, Dario S. | |
| Author | Kobayashi, Koichi S. | |
| Access date | 2023-07-19T19:57:41Z | |
| Available date | 2023-07-19T19:57:41Z | |
| Document date | 2011 | |
| Citation | CAETANO, Braulia Costa et al. Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii. Eur J Immunol., v. 41, n. 12, p. 3627-3631. doi: 10.1002/eji.201141876. | en_US |
| ISSN | 0014-298 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59688 | |
| Language | eng | en_US |
| Publisher | Wiley-VCH | en_US |
| Rights | restricted access | |
| Title | Intrinsic expression of Nod2 in CD4(+) T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii | en_US |
| Type | Article | |
| DOI | 10.1002/eji.201141876 | |
| Abstract | Nod2 belongs to the nucleotide-binding domain leucine-rich repeat family of proteins and senses bacterial cell wall components to initiate innate immune responses against various pathogens. Recently, it has been reported that T-cell-intrinsic expression of Nod2 promotes host defense against Toxoplasma gondii infection by inducing type 1 immunity. Here, we present results that demonstrate that Nod2 does not play a role in the defense against T. gondii infection. Nod2-deficient mice were fully capable of inducing Th1 immune responses and did not show enhanced susceptibility to infection. Upon TCR stimulation in vitro, Nod2-deficient CD4+ T cells showed normal activation, IL-2 production, proliferation, and Th1/2 differentiation. Nod2 mRNA and protein were expressed in CD4+ T and CD8+ T cells at substantial levels. Therefore, Nod2, although expressed in CD4+ T cells, does not have an intrinsic function in T-cell activation and differentiation. | en_US |
| Affilliation | Department of Medicine. University of Massachusetts Medical School. Worcester, MA, USA | en_US |
| Affilliation | Department of Cancer Immunology & AIDS. Dana-Farber Cancer Institute. Boston, MA, USA/of Pathology. Harvard Medical School. Boston, MA, USA | en_US |
| Affilliation | Department of Cell Biology. University of São Paulo. School of Medicine of Ribeirão Preto. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Department of Biochemistry and Immunology. University of São Paulo. School of Medicine of Ribeirão Preto. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Department of Biochemistry and Immunology. University of São Paulo. School of Medicine of Ribeirão Preto. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Department of Cell Biology. University of São Paulo. School of Medicine of Ribeirão Preto. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Department of Cancer Immunology & AIDS. Dana-Farber Cancer Institute. Boston, MA, USA/Department of Pathology. Harvard Medical School. Boston, MA, USA | en_US |
| Affilliation | Department of Biochemistry and Immunology. University of São Paulo. School of Medicine of Ribeirão Preto. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Department of Medicine. University of Massachusetts Medical School. Worcester, MA, USA/ Rene Rachou Research Centre. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brasil | en_US |
| Affilliation | Department of Cell Biology. University of São Paulo. School of Medicine of Ribeirão Preto. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Department of Cancer Immunology & AIDS. Dana-Farber Cancer Institute. Boston, MA, USA/Department of Pathology. Harvard Medical School. Boston, MA, USA | en_US |
| Subject | Toxoplasma gondii | en_US |
| Subject | Nod2 | en_US |
| Subject | NLR proteins | en_US |
| Embargo date | 2099-12-31 | |
