| Author | Nascimento, Rodolfo Duarte | |
| Author | Lisboa, André de Souza | |
| Author | Fujiwara, Ricardo Toshio | |
| Author | Freitas, Michelle Aparecida Ribeiro de | |
| Author | Adad, Sheila Jorge | |
| Author | Oliveira, Rodrigo Correa | |
| Author | Reis, Débora d'Ávila | |
| Author | Silveira, Alexandre Barcelos Morais da | |
| Access date | 2023-07-28T14:24:26Z | |
| Available date | 2023-07-28T14:24:26Z | |
| Document date | 2010 | |
| Citation | NASCIMENTO, Rodolfo Duarte et al. Characterization of enteroglial cells and denervation process in chagasic patients with and without megaesophagus. Hum Pathol., v. 41, n. 4, p. 528-534, 2010. doi: 10.1016/j.humpath.2009.05.018. | en_US |
| ISSN | 0046-8177 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59825 | |
| Language | eng | en_US |
| Publisher | W B Saunders | en_US |
| Rights | restricted access | |
| Title | Characterization of enteroglial cells and denervation process in chagasic patients with and without megaesophagus | en_US |
| Type | Article | |
| DOI | 10.1016/j.humpath.2009.05.018 | |
| Abstract | Chagas disease is caused by infestation with the parasite Trypanosoma cruzi., and some patients who are serologically positive develop chronic megaesophagus, whereas others are symptom-free. Gastrointestinal form of Chagas disease involves an inflammatory invasion of the enteric plexuses and degeneration of enteric neurons and previous works related that enteroglial cells would be involved in enteric inflammatory responses. Because of this, the aims of this study were to determine the relation of enteroglial cells with the denervation process in chagasic patients with and without megaesophagus and seronegative individuals. Our results indicated that the innervation of the esophageal muscle was substantially reduced in patients with megaesophagus, but asymptomatic seropositive subjects were not different to seronegative controls. Besides, patients with megaesophagus had significant decreased of enteroglial cells labeled with S-100 and glial fibrillary acidic protein, whereas patients without megaesophagus presented an increased of both labels. We believe that enteroglial cells would operate a mechanism of defense in the enteric nervous system against the Trypanosoma cruzi infection, which could prevent the organ denervation and preserve the esophagus function. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departament de Morfologia. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departament de Morfologia. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Setor de Parasitologia. Uberlândia, MG, Brazil | en_US |
| Affilliation | Universidade Federal do Triângulo Mineiro. Departamento de Patologia. Uberaba, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Uberlândia. Instituto de Ciências Biomédicas. Setor de Anatomia Humana. Uberlândia, MG, Brazil | en_US |
| Subject | Chagas disease | en_US |
| Subject | Chagasic megaesophagus | en_US |
| Subject | S-100, GFAP, PGP 9.5 | en_US |
| Embargo date | 3100-12-31 | |
