Author | Neto, Valter Ferreira de Andrade | |
Author | Silva, Tito da | |
Author | Lopes, Lucia M. Xavier | |
Author | Rosário, Virgílio E. do | |
Author | Varotti, Fernando de Pilla | |
Author | Krettli, Antoniana Ursine | |
Access date | 2023-07-28T16:08:15Z | |
Available date | 2023-07-28T16:08:15Z | |
Document date | 2007 | |
Citation | ANDRADE-NETO, Valter F de et al. Antiplasmodial activity of aryltetralone lignans from Holostylis reniformis. Antimicrob Agents Chemother., v. 51, n. 7, p. 2346-2350. doi: 10.1128/AAC.01344-06. | en_US |
ISSN | 0066-4804 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59826 | |
Language | eng | en_US |
Publisher | American Society for Microbiology | en_US |
Rights | restricted access | en_US |
Title | Antiplasmodial activity of aryltetralone lignans from Holostylis reniformis | en_US |
Type | Article | en_US |
DOI | 10.1128/AAC.01344-06 | |
Abstract | Extracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum. The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7 ' R,8S,8 ' S)-3 ',4 '-methylenedioxy-4,5-dimethoxy-2,7 '-cyclolignan-7-one, were isolated and tested in vitro against P. falciparum. The three most active lignans showed 50% inhibitor concentrations of <= 0.32 mu M. An evaluation of minimum lethal dose (30%) values showed low toxicity for these lignans in a hepatic cell line (Hep G2A16). Therefore, these compounds are potential candidates for the development of antimalarial drugs | en_US |
Affilliation | Fundação Oswaldo Cruz Centro de Pesquisas René Rachou. Laboratório de Malaria. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Universidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brazil | en_US |
Affilliation | Universidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brazil | en_US |
Affilliation | Universidade Nova de Lisboa. Centro de Malaria e Doenças Tropicais. Instituto de Higiene e Medicina Tropical. Lisboa, Portugal | en_US |
Affilliation | Fundação Oswaldo Cruz Centro de Pesquisas René Rachou. Laboratório de Malaria. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Fundação Oswaldo Cruz Centro de Pesquisas René Rachou. Laboratório de Malaria. Belo Horizonte, MG, Brazil | en_US |
Embargo date | 2099-12-31 | |