| Author | Schor, Doris | |
| Author | Porto, Luís Cristóvão | |
| Author | Roma, Eric Henrique | |
| Author | Castro‑Alves, Julio | |
| Author | Villela, Anna Paula | |
| Author | Araújo, Abelardo Q. C. | |
| Author | Bonecini‑Almeida, Maria Glória | |
| Access date | 2023-07-28T18:44:05Z | |
| Available date | 2023-07-28T18:44:05Z | |
| Document date | 2023 | |
| Citation | SCHOR, Doris et al. Putative role of HLA polymorphism among a Brazilian HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) population. Scientific Reports, v. 13, n. 1, p. 1-11, May 2023. | en_US |
| ISSN | 2045-2322 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59835 | |
| Sponsorship | This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico [Grant No. 477734/07-3] and INI/Fiocruz. The funding agency had no role in the study and collection, analysis, and interpretation of data and in writing the manuscript. | en_US |
| Language | eng | en_US |
| Publisher | Nature Publishing Group | en_US |
| Rights | open access | en_US |
| Title | Putative role of HLA polymorphism among a Brazilian HTLV‑1‑associated myelopathy/ tropical spastic paraparesis (HAM/ TSP) population | en_US |
| Type | Article | en_US |
| DOI | 10.1038/s41598-023-34757-w | |
| Abstract | Around ten million people are infected with HTLV-1 worldwide, and 1-4% develop HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), characterized by an important degeneration of the spinal cord, which can lead to death. Distinct HLA alleles have been associated with either HAM/TSP susceptibility or protection. However, these HLA alleles set may change according to the population studied. Brazil is the second country in the number of HTLV-1-infected people and there are few reports addressing the HLA influence on HTLV-1 infection as well as on disease outcome. The objective of this study was to evaluate the influence of HLA alleles as a risk factor for HAM/TSP and the proviral load (PVL) levels, clinical progression, and death outcomes in an admixed Brazilian population. The HLA-A, -B, -C, and -DRB1 were genotyped in 375 unrelated HTLV-1-infected individuals divided into asymptomatic carriers (AC) (n = 165) and HAM/TSP (n = 210) in a longitudinal cohort from 8 to 22 years of follow-up. Because locus B deviated from Hardy-Weinberg Equilibrium for the study groups, the results represented for HLA-B alleles were inconclusive. The alleles HLA-A*68 and -C*07 were related to HAM/TSP risk in multivariate analysis. The alleles HLA-A*33, and -A*36 were associated with protection against disease progression in HAM/TSP patients, while -C*12, -C*14, and -DRB1*08 were associated with increased risk of death. In the AC group, the presence of, -C*06 and -DRB1*15 alleles influenced an increased PVL, in an adjusted linear regression model, while -A*30, -A*34, -C*06, -C*17 and -DRB1*09 alleles were associated with increased PVL in HAM/TSP group compared to HAM/TSP individuals not carrying these alleles. All these alleles were also related to increased PVL associated with clinical progression outcome. Increased PVL associated with the death outcome was linked to the presence of HLA-A*30. PVL has been associated with HLA, and several alleles were related in AC and HAM/TSP patients with or without interacting with clinical progression outcomes. Understanding the prognostic value of HLA in HAM/TSP pathogenesis can provide important biomarkers tools to improve clinical management and contribute to the discovery of new therapeutic interventions. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Imunologia e Imunogenética em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Histocompatibilidade e Criopreservação. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Imunologia e Imunogenética em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Plataforma de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Histocompatibilidade e Criopreservação. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | HTLV‑1 | en_US |
| Subject | Myelopathy tropical spastic paraparesis (HAM/ TSP) | en_US |
| Subject | HTLV‑1‑infected people | en_US |
| e-ISSN | 2045-2322 | |
