| Author | Rodrigues, L. A. | |
| Author | Almeida, A. A. | |
| Author | Agrizii, Ana Paula | |
| Author | Pacheco, N. | |
| Author | Carvalho, B. C. R. | |
| Author | Zanatta, Augusto Seawright | |
| Author | Kohlhoff, Markus | |
| Author | Torres, Carlos Moreira Miquelino Eleto | |
| Author | Bressan, Gustavo Costa | |
| Author | Leite, Joao Paulo Viana | |
| Access date | 2023-08-02T13:38:03Z | |
| Available date | 2023-08-02T13:38:03Z | |
| Document date | 2023 | |
| Citation | RODRIGUES, L. A. et al. Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds. Natural Product Research, p. 1-6, 2023. | en_US |
| ISSN | 1478-6419 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59875 | |
| Language | eng | en_US |
| Publisher | Taylor & Francis Health Sciences | en_US |
| Rights | restricted access | |
| Title | Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds | en_US |
| Type | Article | |
| DOI | 10.1080/14786419.2023.2225689 | |
| Abstract | In the present study, we have evaluated the cytotoxic activity of 282 extracts from 72 native plant species of the Brazilian Atlantic Forest biome. As a result, Casearia arborea and Sorocea hilarii leaves extracts showed cytotoxic activity against three tumour cell lines tested (B16F10, SW480 and Jurkat). After bioassay-guided fractionation, the bioactive fractions were submitted to the dereplication study via High-performance Liquid Chromatography, connected to High-resolution Mass Spectrometry (HPLC-ESI-QTOF/MS) analysis, combined with a Global Natural Products Social Molecular Networking (GNPS) tool. A combination of bioactivity-guided and dereplication approaches resulted in the putative annotation of 27 clerodane diterpenes and 9 flavonoids as main compounds present in the cytotoxic fractions of C. arborea. Regarding the active fraction of S. hilarii, 10 megastigmans, 17 spirostane steroids derivatives and 2 lignans were putatively identified. In conclusion, Casearia arborea and Sorocea hilarii are potential sources of antitumor compounds. | en_US |
| Affilliation | Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brazil. | en_US |
| Affilliation | Universidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Departamento de Engenharia Florestal. Viçosa, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brazil. | en_US |
| Subject | Casearia arborea | en_US |
| Subject | Cytotoxic | en_US |
| Subject | GNPS | en_US |
| Subject | Sorocea hilarii | en_US |
| Subject | Dereplication | en_US |
| Embargo date | 2030-12-31 | |
