| Author | Luo, Chengliang | |
| Author | Yang, Qiang | |
| Author | Liu, Yuancai | |
| Author | Zhou, Shuanhu | |
| Author | Jiang, Jiying | |
| Author | Reiter, Russel J. | |
| Author | Bhattacharya, Pallab | |
| Author | Cui, Yongchun | |
| Author | Yang, Hongwei | |
| Author | Ma, He | |
| Author | Yao, Jiemin | |
| Author | Lawler, Sean E. | |
| Author | Zhang, Xinmu | |
| Author | Fu, Jianfang | |
| Author | Rozental, Renato | |
| Author | Aly, Hany | |
| Author | Johnson, Mark D. | |
| Author | Chiocca, Ennio Antonio | |
| Author | Wang, Xin | |
| Access date | 2023-08-02T13:43:01Z | |
| Available date | 2023-08-02T13:43:01Z | |
| Document date | 2019 | |
| Citation | LUO, Chengliang et al. The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radical Biology and Medicine, v. 130, p. 215-233, Jan. 2019. | en_US |
| ISSN | 0891-5849 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59877 | |
| Description | Renato Rozental - Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. | en_US |
| Sponsorship | Bill and Melinda Gates Foundation, United States (BMGF: 01075000191, to X.W.); the Hubei State Guoqiang Baojianjiu Center for Engineering and Technology Research, Jing Brand Research Institute, China (to X.W.); the Brigham and Women's Hospital BRI Fund to Sustain Research excellence (to X.W.); the National Natural Science Foundation of China (No. 81400999, to C.L.); and the International Postdoctoral Exchange Fellowship Program from the Office of China Postdoctoral Council (No. 20160043, to C.L.) and Soochow University (to C.L.). | en_US |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Previous version | https://www.arca.fiocruz.br/handle/icict/59646 | en_US |
| Rights | restricted access | |
| Title | The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health | en_US |
| Type | Article | |
| DOI | 10.1016/j.freeradbiomed.2018.10.402 | |
| Abstract | Melatonin is a neurohormone associated with sleep and wakefulness and is mainly produced by the pineal gland. Numerous physiological functions of melatonin have been demonstrated including anti-inflammation, suppressing neoplastic growth, circadian and endocrine rhythm regulation, and its potent antioxidant activity as well as its role in regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others. In this review, we summarize the recent advances related to the multiple protective roles of melatonin receptor agonists, melatonin and N-acetylserotonin (NAS), in brain injury, liver damage, and bone health. Brain injury, including traumatic brain injury, ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and newborn perinatal hypoxia-ischemia encephalopathy, is a major cause of mortality and disability. Liver disease causes serious public health problems and various factors including alcohol, chemical pollutants, and drugs induce hepatic damage. Osteoporosis is the most common bone disease in humans. Due in part to an aging population, both the cost of care of fracture patients and the annual fracture rate have increased steadily. Despite the discrepancy in the pathophysiological processes of these disorders, time frames and severity, they may share several common molecular mechanisms. Oxidative stress is considered to be a critical factor in these pathogeneses. We update the current state of knowledge related to the molecular processes, mainly including anti-oxidative stress, anti-apoptosis, autophagy dysfunction, and anti-inflammation as well as other properties of melatonin and NAS. Particularly, the abilities of melatonin and NAS to directly scavenge oxygen-centered radicals and toxic reactive oxygen species, and indirectly act through antioxidant enzymes are disscussed. In this review, we summarize the similarities and differences in the protection provided by melatonin and/or NAS in brain, liver and bone damage. We analyze the involvement of melatonin receptor 1A (MT1), melatonin receptor 1B (MT2), and melatonin receptor 1C (MT3) in the protection of melatonin and/or NAS. Additionally, we evaluate their potential clinical applications. The multiple mechanisms of action and multiple organ-targeted properties of melatonin and NAS may contribute to development of promising therapies for clinical trials. | en_US |
| Affilliation | Harvard Medical School. Brigham and Women’s Hospital. Department of Neurosurgery. Boston, MA, USA. | en_US |
| Affilliation | Jing Brand Research Institute. Hubei Provincial Key Lab for Quality and Safety of Traditional Chinese Medicine Health Food. Daye, Hubei, China. | en_US |
| Affilliation | Jing Brand Research Institute. Hubei Provincial Key Lab for Quality and Safety of Traditional Chinese Medicine Health Food. Daye, Hubei, China. | en_US |
| Affilliation | Harvard Medical School. Brigham and Women’s Hospital. Department of Orthopedic Surgery. Boston, MA, USA. | en_US |
| Affilliation | Harvard Medical School. Brigham and Women’s Hospital. Department of Neurosurgery. Boston, MA, USA / Weifang Medical University. Department of Histology and Embryology. Weifang, Shandong, China. | en_US |
| Affilliation | University Texas Health Science Center. Department of Cellular and Structural Biology. San Antonio, TX, USA. | en_US |
| Affilliation | National Institute of Pharmaceutical Education and Research. Ahmedabad, India. | en_US |
| Affilliation | Harvard Medical School. Brigham and Women’s Hospital. Department of Neurosurgery. Boston, MA, USA. | en_US |
| Affilliation | University of Massachusetts Medical School. Department of Neurosurgery. Worcester, MA, USA. | en_US |
| Affilliation | Guangxi Medical University. Third Affiliated Hospital. Nanning, Guangxi, China. | en_US |
| Affilliation | Guangxi Medical University. Third Affiliated Hospital. Nanning, Guangxi, China. | en_US |
| Affilliation | Harvard Medical School. Brigham and Women’s Hospital. Department of Neurosurgery. Boston, MA, USA. | en_US |
| Affilliation | Harvard Medical School. Brigham and Women’s Hospital. Department of Neurosurgery. Boston, MA, USA. | en_US |
| Affilliation | Fourth Military Medical University. Xijing Hospital. Department of Endocrinology. Xi'an, China. | en_US |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Ciências Biomédicas. Laboratório de Neuroproteção e Estratégias Regenerativas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Cleveland Clinic Children’s Hospital. Department of Neonatology. Cleveland, OH, USA. | en_US |
| Affilliation | University of Massachusetts Medical School. Department of Neurosurgery. Worcester, MA, USA. | en_US |
| Affilliation | Harvard Medical School. Brigham and Women’s Hospital. Department of Neurosurgery. Boston, MA, USA. | en_US |
| Affilliation | Harvard Medical School. Brigham and Women’s Hospital. Department of Neurosurgery. Boston, MA, USA. | en_US |
| Subject | Melatonin | en_US |
| Subject | N-acetylserotonin | en_US |
| Subject | Oxidative stress | en_US |
| Subject | Brain injury | en_US |
| Subject | Liver damage | en_US |
| Subject | Bone health | en_US |
| Subject | Melatonin receptors | en_US |
| e-ISSN | 1873-4596 | |
