| Autor | Junqueira, Caroline Furtado | |
| Autor | Polidoro, Rafael | |
| Autor | Castro, Guilherme | |
| Autor | Absalon, Sabrina | |
| Autor | Liang, Zhitao | |
| Autor | Santara, Sumit Sen | |
| Autor | Crespo, Ângela | |
| Autor | Pereira, Dhelio Batista | |
| Autor | Gazzinelli, Ricardo Tostes | |
| Autor | Dvorin, Jeffrey D. | |
| Autor | Lieberman, Judy | |
| Data de acesso | 2023-08-08T13:22:09Z | |
| Data de disponibilização | 2023-08-08T13:22:09Z | |
| Data do publicação | 2021 | |
| Citação | JUNQUEIRA, Caroline Furtado et al. γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis. Nature Immunology, v. 22, n. 3, p. 347-357, 2021. | en_US |
| ISSN | 1529-2908 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/59923 | |
| Idioma | eng | en_US |
| Editor | Nature America Inc. | en_US |
| Direito Autoral | restricted access | |
| Título | γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis | en_US |
| Tipo do documento | Article | |
| DOI | 10.1038/s41590-020-00847-4 | |
| Resumo em Inglês | Activated Vγδ9Vδ2 (γδ2) T lymphocytes that sense parasite-produced phosphoantigens are expanded in Plasmodium falciparum-infected patients. Although previous studies suggested that γδ2 T cells help control erythrocytic malaria, whether γδ2 T cells recognize infected red blood cells (iRBCs) was uncertain. Here we show that iRBCs stained for the phosphoantigen sensor, butyrophilin 3A1 (BTN3A1). γδ2 T cells formed immune synapses and lysed iRBCs in a contact, phosphoantigen, BTN3A1 and degranulation-dependent manner, killing intracellular parasites. Granulysin released into the synapse lysed iRBCs and delivered death-inducing granzymes to the parasite. All intra-erythrocytic parasites were susceptible, but schizonts were most sensitive. A second protective γδ2 T cell mechanism was identified. In the presence of patient serum, γδ2 T cells phagocytosed and degraded opsonized iRBCs in a CD16-dependent manner, decreasing parasite multiplication. Thus, γδ2 T cells have two ways to control blood stage malaria – γδT cell antigen receptor (TCR)-mediated degranulation and phagocytosis of antibody-coated iRBCs. | en_US |
| Afiliação | Program in Cellular and Molecular Medicine. Boston Children’s Hospital. USA / Department of Pediatrics. Harvard Medical School. USA / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Program in Cellular and Molecular Medicine. Boston Children’s Hospital. USA / Department of Pediatrics. Harvard Medical School. USA. | en_US |
| Afiliação | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Department of Pediatrics. Harvard Medical School. USA / Division of Infectious Diseases. Boston Children’s Hospital. USA. | en_US |
| Afiliação | Program in Cellular and Molecular Medicine. Boston Children’s Hospital. USA / Department of Pediatrics. Harvard Medical School. USA. | en_US |
| Afiliação | Program in Cellular and Molecular Medicine. Boston Children’s Hospital. USA / Department of Pediatrics. Harvard Medical School. USA. | en_US |
| Afiliação | Program in Cellular and Molecular Medicine. Boston Children’s Hospital. USA / Department of Pediatrics. Harvard Medical School. USA. | en_US |
| Afiliação | Centro de Pesquisa em Medicina Tropical. Rondônia, RR, Brazil. | en_US |
| Afiliação | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil / Department of Medicine. University of Massachusetts Medical School. Worcester, MA,USA /F undação Oswaldo Cruz. Instituto René Rachou. Plataforma de Medicina Translacional. Belo Horizonte, MG, Brazil. | en_US |
| Afiliação | Department of Pediatrics. Harvard Medical School. USA / Division of Infectious Diseases. Boston Children’s Hospital. USA. | en_US |
| Afiliação | Program in Cellular and Molecular Medicine. Boston Children’s Hospital. USA / Department of Pediatrics. Harvard Medical School. USA. | en_US |
| Palavras-chave em inglês | Malaria | en_US |
| Palavras-chave em inglês | γδ T cell | en_US |
| Palavras-chave em inglês | Cytotoxicity | en_US |
| Palavras-chave em inglês | Granulysin | en_US |
| Palavras-chave em inglês | Granzyme | en_US |
| Palavras-chave em inglês | Butyrophilin | en_US |
| Palavras-chave em inglês | Antibody-dependent phagocytosis | en_US |
| Data de embargo | 2099-12-31 | |
