| Author | Scarpa, Fabio | |
| Author | Locci, Chiara | |
| Author | Azzena, Ilenia | |
| Author | Casu, Marco | |
| Author | Fiori, Pier Luigi | |
| Author | Ciccozzi, Alessandra | |
| Author | Giovanetti, Marta | |
| Author | Quaranta, Miriana | |
| Author | Ceccarelli, Giancarlo | |
| Author | Pascarella, Stefano | |
| Author | Ciccozzi, Massimo | |
| Author | Sanna, Daria | |
| Access date | 2023-08-17T13:44:57Z | |
| Available date | 2023-08-17T13:44:57Z | |
| Document date | 2023 | |
| Citation | SCARPA, Fabio et al. SARS-CoV-2 Recombinants: Genomic Comparison between XBF and Its Parental Lineages. Microorganisms, v. 11, n. 7, 1824, 2023. doi.org/10.3390/microorganisms11071824. | en_US |
| ISSN | 2076-2607 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/60142 | |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| Title | SARS-CoV-2 Recombinants: Genomic Comparison between XBF and Its Parental Lineages. | en_US |
| Type | Article | en_US |
| Abstract | Recombination events are very common and represent one of the primary drivers of RNA virus evolution. The XBF SARS-CoV-2 lineage is one of the most recently generated recombinants during the COVID-19 pandemic. It is a recombinant of BA.5.2.3 and BA.2.75.3, both descendants of lineages that caused many concerns (BA.5 and BA.2.75, respectively). Here, we performed a genomic survey focused on comparing the recombinant XBF with its parental lineages to provide a comprehensive assessment of the evolutionary potential, epidemiological trajectory, and potential risks. Genetic analyses indicated that although XBF initially showed the typical expansion depicted by a steep curve, causing several concerns, currently there is no indication of significant expansion potential or a contagion rate surpassing that of other currently active or previously prevalent lineages. BSP indicated that the peak has been reached around 19 October 2022 and then the genetic variability suffered slight oscillations until early 5 March 2023 when the population size reduced for the last time starting its last plateau that is still lasting. Structural analyses confirmed its reduced potential, also indicating that properties of NTDs and RBDs of XBF and its parental lineages present no significant difference. Of course, cautionary measures must still be taken and genome-based monitoring remains the best tool for detecting any important changes in viral genome composition | en_US |
| Affilliation | Department of Biomedical Sciences. University of Sassaris. Sassari, Italy | en_US |
| Affilliation | Department of Biomedical Sciences. University of Sassaris. Sassari, Italy/Department of Veterinary Medicines. University of Sassaris. Sassari, Italy | en_US |
| Affilliation | Department of Biomedical Sciences. University of Sassaris. Sassari, Italy/Department of Veterinary Medicines. University of Sassaris. Sassari, Italy | en_US |
| Affilliation | Department of Veterinary Medicines. University of Sassaris. Sassari, Italy | en_US |
| Affilliation | Department of Biomedical Sciences. University of Sassaris. Sassari, Italy/Azienza Ospedaliera Universitaria. Sassari, Italy | en_US |
| Affilliation | Unit of Medical Statistics and Molecular Epidemiology. University Campus Bio-Medico of Rome. Rome, Italy | en_US |
| Affilliation | Sciences and Technologies for Sustainable Development and One Health. University of Campus Bio-Medico of Rome. Rome, Italy/Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Department of Biochemical Sciences “A. Rossi Fanelli”. Sapienza Università di Roma. Rome, Italy | en_US |
| Affilliation | Department of Public Health and Infectious Diseases. University Hospital Policlinico Umberto I. Sapienza University of Rome. Rome, Italy | en_US |
| Affilliation | Department of Biochemical Sciences “A. Rossi Fanelli”. Sapienza Università di Roma. Rome, Italy | en_US |
| Affilliation | Unit of Medical Statistics and Molecular Epidemiology. University Campus Bio-Medico of Rome. Rome, Italy/Campus Bio-Medico. Fondazione Policlinico Universitario. Rome, Italy | en_US |
| Affilliation | Department of Biomedical Sciences. University of Sassaris. Sassari, Italy | en_US |
| Subject | coronavirus | en_US |
| Subject | SARS-CoV-2 | en_US |
| Subject | genetics | en_US |
| Subject | genome diversity | en_US |
| Subject | epidemiology | en_US |
| Subject | recombination event | en_US |
| Subject | electrostatic surface potential | en_US |
| Subject | spike mutations | en_US |
| Subject | interaction energy | en_US |
| xmlui.metadata.dc.subject.ods | 07 Energia limpa e acessível | |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
