| Author | Carvalho, Lucicleide Ângelo Silva Jungles | |
| Author | Oya-Silva, Laís Fernanda | |
| Author | Perussolo, Maiara Carolina | |
| Author | Guaita, Gisele Oliveira | |
| Author | Brito, Júlio César Moreira | |
| Author | Evans, Allan Arnold | |
| Author | Prodocimo, Maritana Mela | |
| Author | Cestari, Marta Margarete | |
| Author | Braga, Tarcio Teodoro | |
| Author | Assis, Helena Cristina Silva de | |
| Access date | 2023-08-22T15:49:56Z | |
| Available date | 2023-08-22T15:49:56Z | |
| Document date | 2023 | |
| Citation | CARVALHO, Lucicleide Ângelo Silva Jungles et al. Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen. Chemosphere, v. 336, n. 139216, p. 1-13, 2023. | en_US |
| ISSN | 0045-6535 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/60191 | |
| Language | por | en_US |
| Publisher | Elsevier | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Fluorquinolone | en_US |
| Title | Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen | en_US |
| Type | Article | en_US |
| DOI | https://doi.org/10.1016/j.chemosphere.2023.139216 | |
| Abstract | Ciprofloxacin (CIP) is an antibiotic commonly used in human and veterinary medicine. It is present in the aquatic environment, but we still know very little about its effect on non-targeted organisms. This study aimed to evaluate the effects of long-term exposure to environmental CIP concentrations (1, 10, and 100 μg.L 1) in males and females of Rhamdia quelen. After 28 days of exposure, we collected the blood for the analysis of hematological and genotoxic biomarkers. Additionally, we measured 17 β-estradiol and 11 keto-testosterone levels. After the euthanasia, we collected the brain and the hypothalamus to analyze acetylcholinesterase (AChE) activity and neurotransmitters, respectively. The liver and gonads were assessed for biochemical, genotoxic, and histopathological biomarkers. At 100 μg.L 1 CIP, we observed genotoxicity in the blood, nuclear morphological changes, apoptosis, leukopenia, and a reduction of AChE in the brain. In the liver was observed oxidative stress and apoptosis. At 10 μg.L 1 CIP, leukopenia, morphological changes, and apoptosis were presented in the blood and a reduction of AChE in the brain. Apoptosis, leukocyte infiltration, steatosis, and necrosis occurred in the liver. Even at the lowest concentration (1 μg.L 1), adverse effects such as erythrocyte and liver genotoxicity, hepatocyte apoptosis, oxidative stress, and a decrease in somatic indexes were observed. The results showed the importance of monitoring CIP concentrations in the aquatic environment that cause sublethal effects on fish. | en_US |
| Affilliation | Universidade Federal do Paraná. Programa de Pós-Graduação em Ecologia e Conservação. Curitiba, PR, Brasil. | en_US |
| Affilliation | Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil. | en_US |
| Affilliation | Instituto de Pesquisa Pelé Pequeno Príncipe. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Departamento de Farmacologia. Curitiba, PR, Brasil. | en_US |
| Affilliation | Universidade Federal do Paraná. Departamento de Farmacologia. Curitiba, PR, Brasil. | en_US |
| Affilliation | Fundação Ezequiel Dias. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Universidade Federal do Paraná. Departamento de Farmacologia. Curitiba, PR, Brasil. / Faculdades Pequeno Príncipe. Faculdade de Medicina. Curitiba, PR, Brasil. | en_US |
| Affilliation | Universidade Federal do Paraná. Departamento de Biologia Celular. Curitiba, PR, Brasil. | en_US |
| Affilliation | Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil. | en_US |
| Affilliation | Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil. | en_US |
| Affilliation | Universidade Federal do Paraná. Programa de Pós-Graduação em Ecologia e Conservação. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Departamento de Farmacologia. Curitiba, PR, Brasil. | en_US |
| Subject | Antibiotic Prophylaxis | en_US |
| Subject | Biomarkers | en_US |
| Subject | Ciprofloxacin | en_US |
| Subject | Genotoxicity | en_US |
| Subject | Fishes | en_US |
| Subject in Spanish | Profilaxis Antibiótica | en_US |
| Subject in Spanish | Biomarcadores | en_US |
| Subject in Spanish | Ciprofloxacina | en_US |
| Subject in Spanish | Genotoxicidad | en_US |
| Subject in Spanish | Peces | en_US |
| Subject in French | Antibioprophylaxie | en_US |
| Subject in French | Marqueurs biologiques | en_US |
| Subject in French | Ciprofloxacine | en_US |
| Subject in French | Génotoxicité | en_US |
| Subject in French | Poissons | en_US |
| DeCS | Antibioticoprofilaxia | en_US |
| DeCS | Biomarcadores | en_US |
| DeCS | Ciprofloxacina | en_US |
| DeCS | Genotoxicidade | en_US |
| DeCS | Peixes | en_US |
| xmlui.metadata.dc.subject.ods | 14 Vida na água | |
