| Author | Zangeneh, Sahar Z. | |
| Author | Wilson, Ethan A. | |
| Author | Ahluwalia, Surabhi | |
| Author | Donnell, Deborah J. | |
| Author | Ying, Q. Chen | |
| Author | Grinsztejn, Beatriz | |
| Author | Melo, Marineide G. | |
| Author | Godbole, Sheela V. | |
| Author | Hosseinipour, Mina C. | |
| Author | Taha, Taha | |
| Author | Kumwenda, Johnston | |
| Author | McCauley, Marybeth | |
| Author | Cohen, Myron S. | |
| Author | Nielsen-Saines, Karin | |
| Access date | 2023-08-23T13:02:13Z | |
| Available date | 2023-08-23T13:02:13Z | |
| Document date | 2023 | |
| Citation | ZANGENEH, Sahar Z. et al. Pregnancy rates and clinical outcomes among women living with HIV enrolled in HPTN 052. AIDS Care, v. 35, n. 6, p. 824-832, June 2023. | en_US |
| ISSN | 0954-0121 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/60197 | |
| Sponsorship | This research was partially supported by the National Insti-tutes of Allergy and Infectious Diseases of the National Institutes of Health under awards UM1AI068617-15 andUM1-AI068619. The content is solely the responsibility ofthe authors and does not necessarily represent the officialviews of the National Institutes of Health. | en_US |
| Language | eng | en_US |
| Publisher | Carfax | en_US |
| Rights | restricted access | |
| Title | Pregnancy rates and clinical outcomes among women living with HIV enrolled in HPTN 052 | en_US |
| Type | Article | |
| DOI | 10.1080/09540121.2022.2141187 | |
| Abstract | HPTN 052 was a multi-country clinical trial of cART for preventing heterosexual HIV-1 transmission. The study allowed participation of pregnant women and provided access to cART and contraceptives. We explored associations between pregnancy and clinical measures of HIV disease stage and progression. Of 869 women followed for 5.70 (SD = 1.62) years, 94.7% were married/cohabitating, 96% initiated cART, and 76.3% had >2 past pregnancies. Of 337 women who experienced pregnancy, 89.3% were from countries with lower contraceptive coverage, 56.1% first started cART with PI-based regimens and 57.6% were 25-34 years old. Mean cART duration and condom use were similar among pregnant and nonpregnant individuals. Adjusting for confounders, viral load suppression (VLS) was not (aHR(CI) = 0.82(0.61, 1.08)) and CD4 was slightly associated with decreased rates of first pregnancy over time (aHR(CI) = 0.9(0.84, 0.95)); baseline VLS was associated with increased (aRR(CI) = 2.48(1.71, 3.59)) and baseline CD4 was slightly associated with decreased number of pregnancies (aRR(CI) = 0.9(0.85,0.96)) over study duration. Partner seroconversion was univariably associated with higher rates of first pregnancy (HR(CI) = 2.02(1.32,3.07)). Despite a background of higher maternal morbidity and mortality rates, our findings suggest that becoming pregnant does not pose a threat to maternal health in women with HIV when there is access to medical care and antiretroviral treatment. | en_US |
| Affilliation | RTI International, Research Triangle Park. NC, USA / Fred Hutchinson Cancer Research Center. Seattle, WA, USA / University of Washington. Seattle, WA, USA. | en_US |
| Affilliation | Fred Hutchinson Cancer Research Center, Seattle, WA, USA. | en_US |
| Affilliation | Fred Hutchinson Cancer Research Center, Seattle, WA, USA. | en_US |
| Affilliation | Fred Hutchinson Cancer Research Center. Seattle, WA, USA / University of Washington. Seattle, WA, USA. | en_US |
| Affilliation | Stanford University School of Medicine, Stanford, CA, USA. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Hospital Nossa Senhora da Conceição, Porto Alegre, RS, Brazil. | en_US |
| Affilliation | ICMR-National AIDS Research Institute. Pune, India. | en_US |
| Affilliation | University of North Carolina Chapel Hill. Chapel Hill, NC, USA / UNC Project. Lilongwe, Malawi. | en_US |
| Affilliation | Center for Global Health, Bloomberg School of Public Health. Johns Hopkins University. Baltimore, MD, USA. | en_US |
| Affilliation | College of Medicine. University of Malawi. Blantyre, Malawi. | en_US |
| Affilliation | Family Health International 360. Washington, DC, USA. | en_US |
| Affilliation | University of North Carolina Chapel Hill. Chapel Hill, NC, USA. | en_US |
| Affilliation | David Geffen UCLA School of Medicine. University of California Los Angeles. Los Angeles, CA, USA. | en_US |
| Subject | Combination antiretroviral therapy (cART) | en_US |
| Subject | HIV | en_US |
| Subject | Contraception | en_US |
| Subject | Pregnancy | en_US |
| Subject | Women living with HIV (WLH) | en_US |
| Subject | Women’s health | en_US |
| e-ISSN | 0954-0121 | |
| Embargo date | 2030-12-31 | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
