| Author | Santos, Renan Martins dos | |
| Author | Costa, Gustavo | |
| Author | Cerávolo, Isabela Pena | |
| Author | Dias-Souza, Marcus Vinícius | |
| Access date | 2023-09-11T17:26:17Z | |
| Available date | 2023-09-11T17:26:17Z | |
| Document date | 2020 | |
| Citation | DOS SANTOS, Renan Martins et al. Antibiofilm potential of Psidium guajava and Passiflora edulis pulp extracts against Staphylococcus aureus, cytotoxicity, and interference on the activity of antimicrobial drugs. Futur J Pharm Sci., v. 6, 48, 2020. doi.org/10.1186/s43094-020-00056-8 | en_US |
| ISSN | 2314-7253 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/60427 | |
| Language | eng | en_US |
| Publisher | Springer | en_US |
| Rights | restricted access | en_US |
| Title | Antibiofilm potential of Psidium guajava and Passiflora edulis pulp extracts against Staphylococcus aureus, cytotoxicity, and interference on the activity of antimicrobial drugs | en_US |
| Type | Article | en_US |
| Abstract | Background: Pathogenic strains of Staphylococcus aureus can cause several diseases including septicemia and endocarditis, in spite of being a commensal species of the human microbiota. The current drug resistance of S. aureus raises the need for new antimicrobials, and natural products represent a feasible source for prospection of such compounds, due to features including the diversity of structures and mechanisms of action. Here, we provide evidence of the antimicrobial activity of methanolic of Psidium guajava and Passiflora edulis pulps against planktonic cells and biofilms of clinical isolates of S. aureus.
Results: The extracts were effective against the strains in concentrations up to 7.81 and 250 μg/mL for planktonic cells and biofilms, respectively. Antagonistic interactions of the extracts to antimicrobial drugs were observed. The pulps caused no cytotoxic effects on BGM cells. GC-MS analysis found relevant molecules, and UPLC analysis suggested the presence of flavonoids. To the best of our knowledge, this is the first antibiofilm evidence of such extracts.
Conclusion: The extracts seem to be safe and effective enough for more studies aiming at exploring isolated antimicrobial molecules using in vivo models for the treatment of staphylococcal diseases. | en_US |
| Affilliation | Clinical Analysis Laboratory. Pitagoras College. Ipatinga, MG, Brazil/Integrated Pharmacology and Drug Interactions Research Group. Ipatinga, MG, Brazil. | en_US |
| Affilliation | University Center of Caratinga. Caratinga, MG, Brazil. | en_US |
| Affilliation | René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Clinical Analysis Laboratory. Pitagoras College. Ipatinga, MG, Brazil/Integrated Pharmacology and Drug Interactions Research Group. Ipatinga, MG, Brazil. | en_US |
| Subject | Staphylococcus aureus | en_US |
| Subject | Fruit pulp | en_US |
| Subject | Psidium guajava | en_US |
| Subject | Passiflora edulis | en_US |
| Embargo date | 2030-12-31 | |
