| Author | Cerávolo, Isabela Pena | |
| Author | Sanchez, Bruno Antonio Marinho | |
| Author | Sousa, Tais Nóbrega | |
| Author | Guerra, Bruna Mazoni | |
| Author | Soares, I S | |
| Author | Braga, E M | |
| Author | McHenry, A M | |
| Author | Adams, J H | |
| Author | Brito, Cristiana Ferreira Alves | |
| Author | Carvalho, Luzia Helena | |
| Access date | 2023-09-12T18:54:34Z | |
| Available date | 2023-09-12T18:54:34Z | |
| Document date | 2009 | |
| Citation | CERÁVOLO, Isabela Pena et al. Naturally acquired inhibitory antibodies to Plasmodium vivax Duffy binding protein are short-lived and allele-specific following a single malaria infection. Clin Exp Immunol., v. 156, n. 3, p. 502-510, 2009. doi: 10.1111/j.1365-2249.2009.03931.x. | en_US |
| ISSN | 0009-9104 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/60436 | |
| Language | eng | en_US |
| Publisher | Oxford University Press | en_US |
| Rights | restricted access | |
| Subject in Portuguese | Plasmodium vivax | en_US |
| Subject in Portuguese | malaria | en_US |
| Title | Naturally acquired inhibitory antibodies to Plasmodium vivax Duffy binding protein are short-lived and allele-specific following a single malaria infection. | en_US |
| Type | Article | |
| Abstract | The Duffy binding protein of Plasmodium vivax (DBP) is a critical adhesion ligand that participates in merozoite invasion of human Duffy-positive erythrocytes. A small outbreak of P. vivax malaria, in a village located in a non-malarious area of Brazil, offered us an opportunity to investigate the DBP immune responses among individuals who had their first and brief exposure to malaria. Thirty-three individuals participated in the five cross-sectional surveys, 15 with confirmed P. vivax infection while residing in the outbreak area (cases) and 18 who had not experienced malaria (non-cases). In the present study, we found that only 20% (three of 15) of the individuals who experienced their first P. vivax infection developed an antibody response to DBP; a secondary boosting can be achieved with a recurrent P. vivax infection. DNA sequences from primary/recurrent P. vivax samples identified a single dbp allele among the samples from the outbreak area. To investigate inhibitory antibodies to the ligand domain of the DBP (cysteine-rich region II, DBP(II)), we performed in vitro assays with mammalian cells expressing DBP(II) sequences which were homologous or not to those from the outbreak isolate. In non-immune individuals, the results of a 12-month follow-up period provided evidence that naturally acquired inhibitory antibodies to DBP(II) are short-lived and biased towards a specific allele. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Malaria Laboratory. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Malaria Laboratory. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Malaria Laboratory. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biológicas. São Paulo, SP | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | University of South Florida. Tampa, FL, USA | en_US |
| Affilliation | University of South Florida. Tampa, FL, USA | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Malaria Laboratory. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Malaria Laboratory. Belo Horizonte, MG, Brazil. | en_US |
| Subject | Plasmodium vivax | en_US |
| Subject | malaria | en_US |
| Embargo date | 2099-12-31 | |
