| Author | Cerávolo, Isabela Pena | |
| Author | Bruña-Romero, Oscar | |
| Author | Braga, Erika M | |
| Author | Fontes, Cor Jesus Fernandes | |
| Author | Brito, Cristiana Ferreira Alves | |
| Author | Souza, José M | |
| Author | Krettli, Antoniana Ursine | |
| Author | Adams, John H | |
| Author | Carvalho, Luzia Helena | |
| Access date | 2023-09-12T19:04:07Z | |
| Available date | 2023-09-12T19:04:07Z | |
| Document date | 2005 | |
| Citation | CERÁVOLO, Isabela Pena et al. Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon. Am J Trop Med Hyg., v. 72, n. 6, p. 675-81, 2005. | en_US |
| ISSN | 0002-9637 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/60437 | |
| Language | eng | en_US |
| Publisher | American Society of Tropical Medicine and Hygiene | en_US |
| Rights | restricted access | |
| Subject in Portuguese | Plasmodium vivax | en_US |
| Subject in Portuguese | malaria | en_US |
| Title | Anti-Plasmodium vivax duffy binding protein antibodies measure exposure to malaria in the Brazilian Amazon. | en_US |
| Type | Article | |
| Abstract | Plasmodium vivax Duffy binding protein (DBP) is functionally important in the erythrocyte invasion process and provides a logical target for vaccine-mediated immunity. In the current study, we demonstrated that DBP is naturally immunogenic in different populations of the Brazilian Amazon, and the proportions of DBP IgG positive subjects increased with exposure to malaria, reaching a peak in those subjects with long-term exposure (> 15 years) in the Amazon area. This profile of antibody response was significantly different from the one observed for the P. vivax merozoite surface protein 1 (MSP119), which was relatively uniform in areas with markedly different levels of malária transmission. In a small sample of adults with symptomless P. vivax infection, we could not detect any significant correlation between antibodies against these P. vivax proteins and asymptomatic infection. Our study provided na additional insight by demonstrating cumulative exposure as a determinant that acts independently of host age in generation of anti-DBP IgG response | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Minas Gerais Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Universidade Federal de Mato Grosso. Cuiabá, MT, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Instituto Evandro Chagas. Belém, PA, Brazil | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil | en_US |
| Affilliation | Department of Biological Sciences. University of Notre Dame. Notre Dame, Indiana | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou Belo Horizonte, MG, Brazil | en_US |
| Subject | Plasmodium vivax | en_US |
| Subject | malarie | en_US |
| Embargo date | 3100-12-31 | |
