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| Autor | Piccardi, Margherita | |
| Autor | Gentiluomo, Manuel | |
| Autor | Bertoncini, Stefania | |
| Autor | Pezzilli, Raffaele | |
| Autor | Erőss, Bálint | |
| Autor | Bunduc, Stefania | |
| Autor | Uzunoglu, Faik G. | |
| Autor | Talar‑Wojnarowska, Renata | |
| Autor | Vanagas, Tomas | |
| Autor | Sperti, Cosimo | |
| Autor | Oliverius, Martin | |
| Autor | Aoki, Mateus Nóbrega | |
| Autor | Ermini, Stefano | |
| Autor | Hussein, Tamás | |
| Autor | Boggi, Ugo | |
| Autor | Jamroziak, Krzysztof | |
| Autor | Maiello, Evaristo | |
| Autor | Morelli, Luca | |
| Autor | Vodickova, Ludmila | |
| Autor | Di Franco, Gregorio | |
| Autor | Landi, Stefano | |
| Autor | Szentesi, Andrea | |
| Autor | Lovecek, Martin | |
| Autor | Puzzono, Marta | |
| Autor | Tavano, Francesca | |
| Autor | Laarhoven, Hanneke W. M. van | |
| Autor | Zerbi, Alessandro | |
| Autor | Mohelnikova‑Duchonova, Beatrice | |
| Autor | Stocker, Hannah | |
| Autor | Costello, Eithne | |
| Autor | Capurso, Gabriele | |
| Autor | Ginocchi, Laura | |
| Autor | Lawlor, Rita T. | |
| Autor | Vanella, Giuseppe | |
| Autor | Bazzocchi, Francesca | |
| Autor | Izbicki, Jakob R. | |
| Autor | Latiano, Anna | |
| Autor | Bueno‑de‑Mesquita, Bas | |
| Autor | Pisani, Ruggero Ponz de Leon | |
| Autor | Schöttker, Ben | |
| Autor | Soucek, Pavel | |
| Autor | Hegyi, Péter | |
| Autor | Gazouli, Maria | |
| Autor | Hackert, Thilo | |
| Autor | Kupcinskas, Juozas | |
| Autor | Poskiene, Lina | |
| Autor | Tacelli, Matteo | |
| Autor | Roth, Susanne | |
| Autor | Carrara, Silvia | |
| Autor | Perri, Francesco | |
| Autor | Hlavac, Viktor | |
| Autor | Theodoropoulos, George E. | |
| Autor | Busch, Olivier R. | |
| Autor | Mambrini, Andrea | |
| Autor | Eijck, Casper H. J. van | |
| Autor | Arcidiacono, Paolo | |
| Autor | Scarpa, Aldo | |
| Autor | Pasquali, Claudio | |
| Autor | Basso, Daniela | |
| Autor | Lucchesi, Maurizio | |
| Autor | Milanetto, Anna Caterina | |
| Autor | Neoptolemos, John P. | |
| Autor | Cavestro, Giulia Martina | |
| Autor | Janciauskas, Dainius | |
| Autor | Chen, Xuechen | |
| Autor | Chammas, Roger | |
| Autor | Goetz, Mara | |
| Autor | Brenner, Hermann | |
| Autor | Archibugi, Livia | |
| Autor | Dannemann, Michael | |
| Autor | Canzian, Federico | |
| Autor | Tofanelli, Sergio | |
| Autor | Campa, Daniele | |
| Fecha de acceso | 2023-10-06T17:25:18Z | |
| Fecha de disponibilización | 2023-10-06T17:25:18Z | |
| Fecha de publicación | 2023 | |
| Referencia | PICCARDI, Margherita et al. Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians. Biological Research. v. 56, n. 46, p. 1-9, 2023. | en_US |
| ISSN | 0717-6287 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/60727 | |
| Idioma | por | en_US |
| Editor | BMC | en_US |
| Derechos de autor | open access | en_US |
| Palabras clave en Portugués | SNPs | en_US |
| Título | Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians | en_US |
| Tipo del documento | Article | en_US |
| Resumen en Inglés | The genomes of present-day non-Africans are composed of 1–3% of Neandertal-derived DNA as a consequence of admixture events between Neandertals and anatomically modern humans about 50–60 thousand years ago. Neandertal-introgressed single nucleotide polymorphisms (aSNPs) have been associated with modern human disease-related traits, which are risk factors for pancreatic ductal adenocarcinoma (PDAC), such as obesity, type 2 diabetes, and inflammation. In this study, we aimed at investigating the role of aSNPs in PDAC in three Eurasian populations. Results The high-coverage Vindija Neandertal genome was used to select aSNPs in non-African populations from 1000 Genomes project phase 3 data. Then, the association between aSNPs and PDAC risk was tested independently in Europeans and East Asians, using existing GWAS data on more than 200.000 individuals. | en_US |
| Afiliación | Department of Biology. Unit of Genetics. University of Pisa. Pisa, Italy. | en_US |
| Afiliación | Department of Biology. Unit of Genetics. University of Pisa. Pisa, Italy. | en_US |
| Afiliación | Department of Biology. Unit of Zoology and Anthropology. University of Pisa. Pisa, Italy. | en_US |
| Afiliación | Potenza County Medical Association. Potenza, Italy. | en_US |
| Afiliación | Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. | en_US |
| Afiliación | Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / Centre for Translational Medicine. Semmelweis University. Budapest, Hungary. / Division of Pancreatic Diseases. Heart and Vascular Center. Semmelweis University. Budapest, Hungary. / Carol Davila University of Medicine and Pharmacy. Bucharest, Romania. | en_US |
| Afiliación | Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany. | en_US |
| Afiliación | Department of Digestive Tract Diseases. Medical University of Lodz. Lodz, Poland. | en_US |
| Afiliación | Department of Surgery. Lithuanian University of Health Sciences. Kaunas, Lithuania. | en_US |
| Afiliación | Department DISCOG. Chirurgia Generale 1. University of Padova. Padua, Italy. | en_US |
| Afiliación | Department of Surgery. Third Faculty of Medicine. University Hospital Kralovske Vinohrady. Charles University. Prague, Czech Republic. | en_US |
| Afiliación | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | en_US |
| Afiliación | Blood Transfusion Service. Azienda Ospedaliero-Universitaria Meyer. Children’s Hospital. Florence, Italy. | en_US |
| Afiliación | Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. | en_US |
| Afiliación | Division of General and Transplantation Surgery. University of Pisa. Pisa, Italy. | en_US |
| Afiliación | Department of Hematology. Transplantation and Internal Medicine. Medical University of Warsaw. Warsaw, Poland. | en_US |
| Afiliación | Department of Oncology. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo. Foggia, Italy. | en_US |
| Afiliación | Department of Translational Research and New Technologies in Medicine and Surgery. General Surgery Unit. University of Pisa. Pisa, Italy. | en_US |
| Afiliación | Department of Molecular Biology of Cancer. Institute of Experimental Medicine of the Czech Academy of Sciences. Prague, Czechia. / Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia. / Institute of Biology and Medical Genetics. First Faculty of Medicine. Charles University. Prague, Czech Republic. | en_US |
| Afiliación | Department of Translational Research and New Technologies in Medicine and Surgery. General Surgery Unit. University of Pisa. Pisa, Italy. | en_US |
| Afiliación | Department of Biology. Unit of Genetics. University of Pisa. Pisa, Italy. | en_US |
| Afiliación | Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / János Szentágothai Research Center. University of Pécs. Pécs, Hungary. / Centre for Translational Medicine. Semmelweis University. Budapest, Hungary. | en_US |
| Afiliación | Department of Surgery I. University Hospital Olomouc. Olomouc, Czech Republic. | en_US |
| Afiliación | Gastroenterology and Gastrointestinal Endoscopy Unit. Vita-Salute San Raffaele University. IRCCS San Raffaele Scientific Institute. Milan, Italy. | en_US |
| Afiliación | Division of Gastroenterology and Research Laboratory. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy. | en_US |
| Afiliación | Department of Medical Oncology. Amsterdam UMC. Cancer Center Amsterdam. University of Amsterdam. Amsterdam, The Netherlands. | en_US |
| Afiliación | Pancreatic Unit. IRCCS Humanitas Research Hospital. Milan, Italy. / Department of Biomedical Sciences. Humanitas University. Milan, Italy. | en_US |
| Afiliación | Department of Oncology. Faculty of Medicine and Dentistry. Palacky University. Olomouc, Czech Republic. | en_US |
| Afiliación | Division of Clinical Epidemiology and Aging Research. German Cancer Research Center. Heidelberg, Germany. / Network Aging Research. Heidelberg University. Heidelberg, Germany. | en_US |
| Afiliación | Department of Molecular & Clinical Cancer Medicine. University of Liverpool. Liverpool, UK. | en_US |
| Afiliación | Digestive and Liver Disease Unit. Sant’Andrea Hospital. Rome, Italy. / Pancreas Translational and Clinical Research Center. Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. San Raffaele Scientific Institute IRCCS. Milan, Italy. | en_US |
| Afiliación | Oncological Department. Oncology of Massa Carrara. ASL Toscana Nord Ovest. Massa Carrara, Italy. | en_US |
| Afiliación | ARC‑NET Research Centre and Department of Diagnostics and Public Health. Section of Pathology. University of Verona. Verona, Italy. | en_US |
| Afiliación | Digestive and Liver Disease Unit. Sant’Andrea Hospital. Rome, Italy. / Pancreas Translational and Clinical Research Center. Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. San Raffaele Scientific Institute IRCCS. Milan, Italy. | en_US |
| Afiliación | Department of Oncology. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo. Foggia, Italy. | en_US |
| Afiliación | Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany. | en_US |
| Afiliación | Division of Gastroenterology and Research Laboratory. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy. | en_US |
| Afiliación | Centre for Nutrition. Prevention and Health Services. National Institute for Public Health and the Environment. Bilthoven, The Netherlands. | en_US |
| Afiliación | Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. Pancreas Translational and Clinical Research Center. San Raffaele Scientific Institute IRCCS. Milan, Italy. | en_US |
| Afiliación | Division of Clinical Epidemiology and Aging Research. German Cancer Research Center. Heidelberg, Germany. / Network Aging Research. Heidelberg University. Heidelberg, Germany. | en_US |
| Afiliación | Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia. | en_US |
| Afiliación | Institute for Translational Medicine. Medical School. University of Pécs. Pécs, Hungary. / János Szentágothai Research Center. University of Pécs. Pécs, Hungary. / Centre for Translational Medicine. Semmelweis University. Budapest, Hungary. / Division of Pancreatic Diseases. Heart and Vascular Center. Semmelweis University. Budapest, Hungary. | en_US |
| Afiliación | Laboratory of Biology. Medical School. National and Kapodistrian University of Athens. Athens, Greece. | en_US |
| Afiliación | Department of General, Visceral, and Transplantation Surgery. University of Heidelberg. Heidelberg, Germany. | en_US |
| Afiliación | Department of Gastroenterology and Institute for Digestive Research. Lithuanian University of Health Sciences. Kaunas, Lithuania. | en_US |
| Afiliación | Department of Pathology. Lithuanian University of Health Sciences. Kaunas, Lithuania. | en_US |
| Afiliación | Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. Pancreas Translational and Clinical Research Center. San Raffaele Scientific Institute IRCCS. Milan, Italy. | en_US |
| Afiliación | Department of General, Visceral, and Transplantation Surgery. University of Heidelberg. Heidelberg, Germany. | en_US |
| Afiliación | Department of Gastroenterology. Endoscopic Unit. IRCCS Humanitas Research Hospital. Milan, Italy. | en_US |
| Afiliación | Division of Gastroenterology and Research Laboratory. Fondazione IRCCS “Casa Sollievo della Sofferenza” Hospital. San Giovanni Rotondo, Italy. | en_US |
| Afiliación | Biomedical Center. Faculty of Medicine in Pilsen. Charles University. Pilsen, Czechia. | en_US |
| Afiliación | First Department of Propaedeutic Surgery. Hippocration General Hospital. National and Kapodistrian University of Athens. Athens, Greece. | en_US |
| Afiliación | Department of Surgery. Amsterdam UMC. Cancer Center Amsterdam. University of Amsterdam. Amsterdam, the Netherlands. | en_US |
| Afiliación | Oncological Department. Oncology of Massa Carrara. ASL Toscana Nord Ovest. Massa Carrara, Italy. | en_US |
| Afiliación | Department of Surgery. Erasmus MC University Medical Center. Rotterdam, the Netherlands. | en_US |
| Afiliación | Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. Pancreas Translational and Clinical Research Center. San Raffaele Scientific Institute IRCCS. Milan, Italy. | en_US |
| Afiliación | ARC‑NET Research Centre and Department of Diagnostics and Public Health. Section of Pathology. University of Verona. Verona, Italy. | en_US |
| Afiliación | Department DISCOG. Chirurgia Generale 3. University of Padova. Padua, Italy. | en_US |
| Afiliación | Department DIMED. Laboratory Medicine. University of Padova. Padua, Italy. | en_US |
| Afiliación | Oncological Department. Oncology of Massa Carrara. ASL Toscana Nord Ovest. Massa Carrara, Italy. | en_US |
| Afiliación | Department DISCOG. Chirurgia Generale 3. University of Padova. Padua, Italy. | en_US |
| Afiliación | Department of General, Visceral, and Transplantation Surgery. University of Heidelberg. Heidelberg, Germany. | en_US |
| Afiliación | Gastroenterology and Gastrointestinal Endoscopy Unit. Vita-Salute San Raffaele University. IRCCS San Raffaele Scientific Institute. Milan, Italy. | en_US |
| Afiliación | Department of Pathology. Lithuanian University of Health Sciences. Kaunas, Lithuania. | en_US |
| Afiliación | Division of Clinical Epidemiology and Aging Research. German Cancer Research Center. Heidelberg, Germany. / Medical Faculty Heidelberg. University of Heidelberg. Heidelberg, Germany. | en_US |
| Afiliación | Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. / Division of Preventive Oncology. German Cancer Research Center and National Center for Tumor Diseases. Heidelberg, Germany. | en_US |
| Afiliación | Department of General. Visceral and Thoracic Surgery. University Medical Center Hamburg-Eppendorf. Hamburg, Germany. | en_US |
| Afiliación | Division of Clinical Epidemiology and Aging Research. German Cancer Research Center. Heidelberg, Germany. / Division of Preventive Oncology. German Cancer Research Center and National Center for Tumor Diseases. Heidelberg, Germany. / German Cancer Consortium. German Cancer Research Center. Heidelberg, Germany. | en_US |
| Afiliación | Digestive and Liver Disease Unit. Sant’Andrea Hospital. Rome, Italy. / Pancreas Translational and Clinical Research Center. Pancreato‑Biliary Endoscopy and Endoscopic Ultrasound. San Raffaele Scientific Institute IRCCS. Milan, Italy. | en_US |
| Afiliación | Estonian Biocentre. Institute of Genomics. University of Tartu. Tartu, Estonia. | en_US |
| Afiliación | Genomic Epidemiology Group. German Cancer Research Center. Heidelberg, Germany. | en_US |
| Afiliación | Department of Biology. Unit of Zoology and Anthropology. University of Pisa. Pisa, Italy. | en_US |
| Afiliación | Department of Biology. Unit of Genetics. University of Pisa. Pisa, Italy. | en_US |
| Palavras clave en Inglês | Neanderthals | en_US |
| Palavras clave en Inglês | Polymorphism, Single Nucleotide | en_US |
| Palavras clave en Inglês | Carcinoma, Pancreatic Ductal | en_US |
| Palavras clave | Hombre de Neandertal | en_US |
| Palavras clave | Polimorfismo de Nucleótido Simple | en_US |
| Palavras clave | Carcinoma Ductal Pancreático | en_US |
| Palavras clave en Francês | Néandertaliens | en_US |
| Palavras clave en Francês | Polymorphisme de nucléotide simple | en_US |
| Palavras clave en Francês | Carcinome du canal pancréatique | en_US |
| DeCS | Homem de Neandertal | en_US |
| DeCS | Polimorfismo de Nucleotídeo Único | en_US |
| DeCS | Carcinoma Ductal Pancreático | en_US |
| e-ISSN | 0717-6287 |
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