| Author | Valverde, Suellen Pinheiro Carvalho | |
| Author | Yahouédéhou, Setondji Cocou Modeste Alexandre | |
| Author | Oliveira, Rodrigo Mota de | |
| Author | Veloso, Nathalie Souza | |
| Author | Fonseca, Cleverson Alves | |
| Author | Mendes, Karina Oliveira | |
| Author | Barbosa, Cynara Gomes | |
| Author | Gonçalves, Marilda de Souza | |
| Author | Adôrno, Elisângela Vitória | |
| Access date | 2023-10-17T13:23:48Z | |
| Available date | 2023-10-17T13:23:48Z | |
| Document date | 2022 | |
| Citation | VALVERDE, Suellen Pinheiro Carvalho et al. HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women. Open Journal of Pain Medicine, v. 6, n. 1, p. 1-7, 2022. | en_US |
| ISSN | 2640-8104 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/60818 | |
| Sponsorship | Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES). | en_US |
| Language | eng | en_US |
| Publisher | Peertechz Publications Private Limited | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | HPA-3 | en_US |
| Subject in Portuguese | C807T | en_US |
| Subject in Portuguese | Polimorfismos | en_US |
| Subject in Portuguese | Biomarcadores | en_US |
| Subject in Portuguese | Artéria coronária | en_US |
| Subject in Portuguese | Mulheres brasileiras | en_US |
| Title | HPA-3 and C807T polymorphisms are associated with laboratory biomarkers of coronary artery disease in Brazilian women | en_US |
| Type | Article | en_US |
| DOI | 10.17352/ojpm.000029 | |
| Abstract | Reports describe the association between platelet activation, adhesion, and aggregation, as well as polymorphisms in genes encoding platelet membrane glycoproteins with a predisposition to coronary artery disease (CAD). This study investigates associations between HPA-1, -3 and C807T polymorphisms and CAD. A cross-sectional study involving 114 women who underwent coronary angiography was performed. The CAD+ group consisted of 63 women while the CAD- group of 51 women. Hematological and biochemical parameters were evaluated by electronic methods. Polymorphisms were investigated by PCR-RFLP and PCR-SSP and participants answered an epidemiological questionnaire and provided anthropometric data. Blood pressure was also measured. Statistical analyses were performed using EpiInfo v. 7.0 software. Results showed that age, diabetes mellitus, hypertension, and hyperlipidemia were associated with CAD. In addition, CAD+ women showed elevated glucose, TG, and VLDL-c levels and reduced HDL-c levels. No significant difference was observed between the allelic and genotypic distributions of the polymorphisms HPA-1, -3, and C807T in CAD+ and CAD- groups. However, CAD+ women carriers of the variant 3b allele had elevated TG and sP-selectin levels while the carriers of the variant 807T allele had reduced CT and LDL-c levels. Hence, our data suggest that the polymorphism HPA-3 increases, indirectly, the risk of CAD development and occurrence while polymorphism C807T reduces this effec. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil. | en_US |
| Subject | HPA-3 | en_US |
| Subject | C807T | en_US |
| Subject | Polymorphisms | en_US |
| Subject | Biomarkers | en_US |
| Subject | Coronary artery | en_US |
| Subject | Brazilian women | en_US |
| DeCS | Biomarcadores | en_US |
| DeCS | Doença da Artéria Coronariana | en_US |
| DeCS | Mulheres | en_US |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
