| Author | Souza, Zilyane Cardoso de | |
| Author | Xavier Júnior, Francisco Humberto | |
| Author | Pinheiro, Irapuan Oliveira | |
| Author | Rebouças, Juliana de Souza | |
| Author | Abreu, Brenda Oliveira de | |
| Author | Mesquita, Paulo Roberto Ribeiro | |
| Author | Rodrigues, Frederico de Medeiros | |
| Access date | 2023-10-17T16:50:37Z | |
| Available date | 2023-10-17T16:50:37Z | |
| Document date | 2023 | |
| Citation | SOUZA, Zilyane Cardoso de et al. Ameliorating the antiparasitic activity of the multifaceted drug ivermectin through a polymer nanocapsule formulation. International Journal of Pharmaceutics, v. 639, p. 1-11, 2023. | en_US |
| ISSN | 0378-5173 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/60823 | |
| Sponsorship | Fundação de Amparo a Ciência e Tecnologia de Pernambuco (FACEPE).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Fundação La Caixa.
Fundação Caja Navarra.
Fundação Roviralta.
Ubesol.
Governo de Navarra.
Laser Ebro.
Inversiones Garcilaso de la Vega. | en_US |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Ivermectina | en_US |
| Subject in Portuguese | Poli(ε-caprolactona) | en_US |
| Subject in Portuguese | Nanocápsulas | en_US |
| Subject in Portuguese | Sistema de entrega de medicamentos | en_US |
| Title | Ameliorating the antiparasitic activity of the multifaceted drug ivermectin through a polymer nanocapsule formulation | en_US |
| Type | Article | en_US |
| DOI | 10.1016/j.ijpharm.2023.122965 | |
| Abstract | Ivermectin (IVM) is a potent antiparasitic widely used in human and veterinary medicine. However, the low oral bioavailability of IVM restricts its therapeutic potential in many parasitic infections, highlighting the need for novel formulation approaches. In this study, poly(ε-caprolactone) (PCL) nanocapsules containing IVM were successfully developed using the nanoprecipitation method. Pumpkin seed oil (PSO) was used as an oily core in the developed nanocapsules. Previously, PSO was chemically analyzed by headspace solid-phase microextraction coupled to gas chromatography/mass spectrometry (HS-SPME/GC–MS). The solubility of IVM in PSO was found to be 4266.5 ± 38.6 μg/mL. In addition, the partition coefficient of IVM in PSO/water presented a logP of 2.44. A number of nanocapsule batches were produced by factorial design resulting in an optimized formulation. Negatively charged nanocapsules measuring around 400 nm demonstrated unimodal size distribution, and presented regular spherical morphology under transmission electron microscopy. High encapsulation efficiency (98–100%) was determined by HPLC. IVM-loaded capsules were found to be stable in nanosuspensions at 4 °C and 25 °C, with no significant variations in particle size observed over a period of 150 days. Nanoencapsulated IVM (0.3 mM) presented reduced toxicity to J774 macrophages and L929 fibroblasts compared to free IVM. Moreover, IVM-loaded nanocapsules also demonstrated enhanced in vitro anthelmintic activity against Strongyloides venezuelensis in comparison to free IVM. Collectively, the present findings demonstrate the promising potential of PCL-PSO nanocapsules to improve the antiparasitic effects exerted by IVM. | en_US |
| Affilliation | Universidade de Pernambuco. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada. Recife, PE, Brasil. | en_US |
| Affilliation | Universidade Federal da Paraíba. Departamento de Farmácia. João Pessoa, PB, Brasil. | en_US |
| Affilliation | Universidade de Pernambuco. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada. Recife, PE, Brasil. | en_US |
| Affilliation | Universidade de Pernambuco. Programa de Pós-Graduação em Ciências da Saúde, Recife, PE, Brasil. | en_US |
| Affilliation | Universidade de Pernambuco. Programa de Pós-Graduação em Ciências da Saúde, Recife, PE, Brasil. | en_US |
| Affilliation | Centro Tecnológico Agropecuário do Estado da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Centro Tecnológico Agropecuário do Estado da Bahia. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Estadual de Campinas. Departamento de Biologia Animal, Campinas, SP, Brasil. | en_US |
| Affilliation | University of Navarra, Institute of Tropical Health. Department of Microbiology and Parasitology. IdiSNA (Navarra Institute for Health Research). Pamplona, Spain. | en_US |
| Affilliation | Universidade Estadual de Campinas. Departamento de Biologia Animal, Campinas, SP, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Estadual de Campinas. Departamento de Biologia Animal, Campinas, SP, Brasil. | en_US |
| Affilliation | University of Navarra, Institute of Tropical Health. Department of Microbiology and Parasitology. IdiSNA (Navarra Institute for Health Research). Pamplona, Spain. | en_US |
| Affilliation | Universidade Estadual de Campinas. Departamento de Biologia Animal, Campinas, SP, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade de Pernambuco. Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | en_US |
| Subject | Ivermectin | en_US |
| Subject | Poly(ε-caprolactone) | en_US |
| Subject | Nanocapsules | en_US |
| Subject | Drug delivery system | en_US |
| DeCS | Ivermectina | en_US |
| DeCS | Nanocápsulas | en_US |
| DeCS | Sistemas de Liberação de Medicamentos | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
