Author | Azevedo, Carine Machado | |
Author | Meira, Cássio Santana | |
Author | Silva, Jaqueline Wang da | |
Author | Moura, Danielle Maria Nascimento | |
Author | Oliveira, Sheilla Andrade de | |
Author | Costa, Cícero Jádson da | |
Author | Santos, Emanuelle de Souza | |
Author | Soares, Milena Botelho Pereira | |
Access date | 2023-10-19T15:06:17Z | |
Available date | 2023-10-19T15:06:17Z | |
Document date | 2023 | |
Citation | AZEVEDO, Carine Machado et al. Therapeutic Potential of Natural Products in the Treatment of Schistosomiasis. Molecules, v. 28, n. 19, p. 1-23, 2023. | en_US |
ISSN | 1420-3049 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/60850 | |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Subject in Portuguese | Esquistossomose | en_US |
Subject in Portuguese | Compostos naturais | en_US |
Subject in Portuguese | Óleo essencial | en_US |
Subject in Portuguese | Ferramentas moleculares | en_US |
Title | Therapeutic potential of natural products in the treatment of schistosomiasis | en_US |
Type | Article | en_US |
DOI | 10.3390/molecules28196807 | |
Abstract | It is estimated that 250 million people worldwide are affected by schistosomiasis. Disease transmission is related to the poor sanitation and hygiene habits that affect residents of impoverished regions in tropical and subtropical countries. The main species responsible for causing disease in humans are Schistosoma Mansoni, S. japonicum, and S. haematobium, each with different geographic distributions. Praziquantel is the drug predominantly used to treat this disease, which offers low effectiveness against immature and juvenile parasite forms. In addition, reports of drug resistance prompt the development of novel therapeutic approaches. Natural products represent an important source of new compounds, especially those obtained from plant sources. This review compiles data from several in vitro and in vivo studies evaluating various compounds and essential oils derived from plants with cercaricidal and molluscicidal activities against both juvenile and adult forms of the parasite. Finally, this review provides an important discussion on recent advances in molecular and computational tools deemed fundamental for more rapid and effective screening of new compounds, allowing for the optimization of time and resources. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Centro Universitário SENAI/CIMATEC. Instituto SENAI de Inovação em Sistemas Avançados em Saúde (CIMATEC ISI SAS). Salvador, BA, Brasil. | en_US |
Affilliation | Centro Universitário SENAI/CIMATEC. Instituto SENAI de Inovação em Sistemas Avançados em Saúde (CIMATEC ISI SAS). Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | en_US |
Affilliation | Centro Universitário SENAI/CIMATEC. Instituto SENAI de Inovação em Sistemas Avançados em Saúde (CIMATEC ISI SAS). Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Centro Universitário SENAI/CIMATEC. Instituto SENAI de Inovação em Sistemas Avançados em Saúde (CIMATEC ISI SAS). Salvador, BA, Brasil. | en_US |
Subject | Schistosomiasis | en_US |
Subject | Natural compounds | en_US |
Subject | Essential oil | en_US |
Subject | Molecular tools | en_US |
DeCS | Esquistossomose | en_US |
DeCS | Óleos Voláteis | en_US |