| Author | Benko, Lorena Macedo Pestana | |
| Author | Silva, Mariana Evangelista de Souza Vieira da | |
| Author | Falcão, Eduardo Mastrangelo Marinho | |
| Author | Freitas, Dayvison Francis Saraiva | |
| Author | Calvet, Guilherme Amaral | |
| Author | Almeida, Marcos de Abreu | |
| Author | Almeida-Paes, Rodrigo | |
| Author | Zancopé-Oliveira, Rosely Maria | |
| Author | Valle, Antonio Carlos Francesconi do | |
| Author | Macedo, Priscila Marques de | |
| Access date | 2023-10-25T16:04:44Z | |
| Available date | 2023-10-25T16:04:44Z | |
| Document date | 2023 | |
| Citation | BENKO, Lorena Macedo Pestana et al. Paracoccidioidomycosis and pregnancy: A 40-year single-center cohort study in the endemic area of Rio de Janeiro, Brazil. PLoS Neglected Tropical Diseases, v. 17, n. 9, p. 1-14, Sept. 2023. | en_US |
| ISSN | 1935-2727 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/60918 | |
| Sponsorship | This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001. This work was supported in part by Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro [FAPERJ E-26/211.430/2021] to PMdM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en_US |
| Language | eng | en_US |
| Publisher | Public Library of Science | en_US |
| Rights | open access | en_US |
| Title | Paracoccidioidomycosis and pregnancy: A 40- year single-center cohort study in the endemic area of Rio de Janeiro, Brazil | en_US |
| Type | Article | en_US |
| DOI | 10.1371/journal.pntd.0011645 | |
| Abstract | The occurrence of acute paracoccidioidomycosis (PCM) in urban areas of the Rio de Janeiro state, Brazil, has emerged in recent years. Therefore, young populations, including pregnant women, are at a higher risk of infection. Furthermore, young women undergoing itraconazole treatment for PCM have increased chances to get pregnant because this medication may reduce the effectiveness of contraceptives. Acute PCM is invasive, reaching abdominal organs, posing a maternal-fetal risk. PCM treatment in pregnant women is also challenging due to the teratogenicity associated with the currently available oral drugs. There are scarce studies on PCM and pregnancy, mainly consisting of case reports and experimental murine models that highlight the severity of this association. We conducted a database research at a PCM reference center in Rio de Janeiro state from 1980 to 2020. We included patients diagnosed with PCM who were pregnant shortly before, at admission, or at any moment of their PCM follow-up care. Data related to pregnancy, childbirth, and the newborn were obtained from the Brazilian official public databases. We also reviewed the epidemiological and clinical features of these patients. During the study period, we identified 18 pregnant patients, with a median age of 26 years (range: 16-38). Among these cases, six (33.3%) were detected in the last 5 years, and 14 (77.8%) presented acute PCM, supporting the recent shift in the epidemiological profile towards acute PCM. Most pregnancies occurred during PCM treatment (n = 11, 61.1%), which led to challenges in the therapeutic management. Maternal-fetal complications occurred in some of these cases, including vaginal bleeding (n = 1), preeclampsia (n = 1), prematurity (n = 2), low birth weight (n = 4), and fetal deaths (n = 2). PCM during pregnancy presents a significant public health concern in the context of the emergence of acute PCM in urban areas. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Infectious Dermatology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Infectious Dermatology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Infectious Dermatology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Infectious Dermatology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Mycology Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Mycology Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Mycology Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Infectious Dermatology. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research on Infectious Dermatology. Rio de Janeiro, RJ, Brazil. | en_US |
| Subject | Paracoccidioidomycosis | en_US |
| Subject | Pregnancy | en_US |
| Subject | Cohort study | en_US |
| Subject | Endemic area | en_US |
| e-ISSN | 1935-2735 | |
