| Author | Green, Rebecca K. | |
| Author | Manchola, Camilo | |
| Author | Gerth-Guyette, Emily | |
| Author | Silva, Michelle Oliveira | |
| Author | Stephanie, Raissa | |
| Author | Soares, Tainá dos Santos | |
| Author | Gottin, Luiza Bastos | |
| Author | Coelho, Milena | |
| Author | Green, Kimberly E. | |
| Author | Costa, Alexandre Dias Tavares | |
| Author | Pereira, Dhélio Batista | |
| Access date | 2023-11-21T16:15:17Z | |
| Available date | 2023-11-21T16:15:17Z | |
| Document date | 2023 | |
| Citation | GREEN, Rebecca K. et al. Integration of serial self-testing for COVID-19 as part of contact tracing in the Brazilian public health system: A pragmatic trial protocol. PLoS ONE, v.18, n. 10, p. 1-11, 2023. | en_US |
| ISSN | 1932-6203 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/61391 | |
| Language | por | en_US |
| Publisher | Public Library of Science | en_US |
| Rights | open access | en_US |
| Title | Integration of serial self-testing for COVID-19 as part of contact tracing in the Brazilian public health system: A pragmatic trial protocol | en_US |
| Type | Article | en_US |
| DOI | https://doi.org/ 10.1371/journal.pone.0284659 | |
| Abstract | The coronavirus disease (COVID-19) pandemic has led to an unprecedented public health crisis. Insufficient testing continues to limit the effectiveness of the global response to the COVID-19 pandemic. Molecular testing methods such as reverse transcriptase polymerase chain reaction (RT-PCR) continue to be highly centralized and are a sub-optimal option for population surveillance. Rapid antigen tests (Ag-RDTs) offer multiple benefits including low costs, high flexibility to conduct tests in a wide variety of settings, and faster return of results. Self-test Ag-RDTs (STs) have gained approval in several markets and offer the possibility to expand testing, reaching at-risk populations. While STs have the potential to assist the COVID-19 response, test result integrity, reporting, and appropriate linkage to care continue to hinder the widespread implementation of self-testing programs. This protocol presents a mixed-methods pragmatic trial (ISRCTN91602092) to better understand the feasibility of self-testing as part of a contact tracing strategy within the Brazilian public health system. Approximately 604 close contacts of 150 index cases testing positive for COVID-19 will be enrolled. Index cases will be randomized for their close contacts to participate in either serial (daily) self-testing over a 10-day follow-up period or a more traditional approach to contact tracing with a professional Ag-RDT at one time point post-exposure. Usability workshops and focus group discussions will also be conducted. This study protocol presents a comprehensive plan to assess the effectiveness, operational feasibility, and stakeholder preferences of a serial self-testing strategy for contact tracing within the Brazilian public health system. Our results will contribute to a better understanding of the feasibility of a self-testing strategy within the public sector. Potential risks and limitations are discussed. Our findings will have important implications as governments continue working to mitigate the impact of COVID-19, particularly in the context of where to direct limited resources for testing and healthcare infrastructure. | en_US |
| Affilliation | PATH. Seattle, Washington, USA. | en_US |
| Affilliation | Global Health Strategies. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | PATH. Seattle, Washington, USA. | en_US |
| Affilliation | Centro de Pesquisa de Medicina Tropical de Rondônia. Porto Velho, RO, Brasil. | en_US |
| Affilliation | Centro de Pesquisa de Medicina Tropical de Rondônia. Porto Velho, RO, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | en_US |
| Affilliation | Global Health Strategies. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Global Health Strategies. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | PATH. Seattle, Washington, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | en_US |
| Affilliation | Centro de Pesquisa de Medicina Tropical de Rondônia. Porto Velho, RO, Brasil. | en_US |
| Subject | Self-Testing | en_US |
| Subject | Pragmatic Clinical Trial | en_US |
| Subject | Health Care Rationing | en_US |
| Subject | Health Planning | en_US |
| Subject in Spanish | Autoevaluación | en_US |
| Subject in Spanish | Ensayo Clínico Pragmático | en_US |
| Subject in Spanish | Asignación de Recursos para la Atención de Salud | en_US |
| Subject in Spanish | Planificación en Salud | en_US |
| Subject in French | Auto-dépistage | en_US |
| Subject in French | Essai clinique pragmatique | en_US |
| Subject in French | Rationnement des services de santé | en_US |
| Subject in French | Planification en santé | en_US |
| DeCS | Autoteste | en_US |
| DeCS | COVID-19 | en_US |
| DeCS | Ensaio Clínico Pragmático | en_US |
| DeCS | Alocação de Recursos para a Atenção à Saúde | en_US |
| DeCS | Planejamento em Saúde | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
